Does Rh immune globulin suppress HLA sensitization in pregnancy?

• Published in: Transfusion (Philadelphia, Pa.) Vol. 53; no. 9; pp. 2069 - 2077
• Main Authors: Kaufman, Richard M., Schlumpf, Karen S., Wright, David J., Triulzi, Darrell J.
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Blackwell Publishing Ltd 01.09.2013; Wiley; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Confidence intervals; Cross-Sectional Studies; Female; HLA Antigens - immunology; Humans; Logistic Models; Medical research; Medical sciences; Middle Aged; Pregnancy; Rho(D) Immune Globulin - immunology; Studies; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Pregnancy; Human; HLA-System; Immunoglobulins; Transfusion; Major histocompatibility system; Female; Sensitization; Woman; Class I histocompatibility antigen

Background How Rh immune globulin (RhIG) prevents sensitization to D antigen is unclear. If RhIG Fc delivers a nonspecific immunosuppressive signal, then RhIG may inhibit sensitization to antigens other than D. HLA antibody prevalence was compared in previously pregnant D– versus D+ women to investi...