The noncanonical NF-κB pathway

• Published in: Immunological reviews Vol. 246; no. 1; pp. 125 - 140
• Main Author: Sun, Shao-Cong
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2012
• Subjects: Animals; cIAP; Humans; NF- Kappa B protein; NF- Kappa B-inducing kinase; NF-kappa B - metabolism; NF-kappa B p52 Subunit - metabolism; NF-kappaB-Inducing Kinase; NIK; noncanonical NF-κB; p100 processing; Protein Serine-Threonine Kinases - metabolism; RelB protein; Signal Transduction; TRAF2; TRAF3; Tumor necrosis factor; Tumor necrosis factor receptors; Ubiquitin-protein ligase; ubiquitination

The noncanonical nuclear factor‐κB (NF‐κB) signaling pathway mediates activation of the p52/RelB NF‐κB complex and, thereby, regulates specific immunological processes. This NF‐κB pathway relies on the inducible processing of NF‐κB2 precursor protein, p100, as opposed to the degradation of IκBα in t...