Neutralization of AntiCitrullinated Protein Antibodies in Rheumatoid Arthritis – A Way to Go?

• Published in: Basic & clinical pharmacology & toxicology Vol. 114; no. 1; pp. 13 - 17
• Main Authors: Cerqueira, Cátia F., Klareskog, Lars, Jakobsson, Per‐Johan
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Blackwell 01.01.2014; Wiley Subscription Services, Inc
• Subjects: Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - immunology; Autoantibodies - blood; Autoantibodies - chemistry; Biological and medical sciences; Citrulline - blood; Citrulline - chemistry; Diseases of the osteoarticular system; Fibrinogen - metabolism; Gene-Environment Interaction; Humans; Inflammatory joint diseases; Medical research; Medical sciences; Medicin och hälsovetenskap; Pharmacology. Drug treatments; Rheumatoid arthritis; Rheumatoid Factor - blood; Immunopathology; Chronic; Antibody; Rheumatoid arthritis; Diseases of the osteoarticular system; Autoimmune disease; Inflammatory joint disease; Protein; Neutralization

Anticitrullinated protein antibodies (ACPAs) constitute a class of autoantibodies found in 60–70% of patients with rheumatoid arthritis (RA). The most common test for ACPA positivity is based on the occurrence of antibodies that bind to circular citrullinated peptides, so‐called CCP, some of which a...