Nonalcoholic fatty liver disease is associated with coronary artery calcification
Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim of this study was to investigate whether NAFLD was associated with coronary artery calcifi...
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| Published in | Hepatology (Baltimore, Md.) Vol. 56; no. 2; pp. 605 - 613 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.08.2012
Wiley Wolters Kluwer Health, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0270-9139 1527-3350 1527-3350 |
| DOI | 10.1002/hep.25593 |
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| Abstract | Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim of this study was to investigate whether NAFLD was associated with coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis independent of computed tomography (CT)‐measured visceral adiposity. Out of 5,648 subjects who visited one of our health screening centers between 2003 and 2008, we enrolled 4,023 subjects (mean age, 56.9 ± 9.4 years; 60.7% males) without known liver disease or a history of ischemic heart disease. CAC score was evaluated using the Agatston method. On univariate analysis, the presence of CAC (score >0) was significantly associated with age, sex, body mass index, aspartate aminotransferase, alanine aminotransferase, high‐density lipoprotein cholesterol, triglycerides, and increased risk of diabetes, hypertension, smoking, and NAFLD. Increasing CAC scores (0, <10, 10‐100, ≥100) were associated with higher prevalence of NAFLD (odds ratio [OR], 1.84; 95% confidence interval [CI], 1.61‐2.10; P<0.001). Multivariable ordinal regression analysis was adjusted for traditional risk factors, and CT‐measured visceral adipose tissue area in a subgroup of subjects showed that the increased CAC scores were significantly associated with the presence of NAFLD (OR, 1.28, 95% CI, 1.04‐1.59; P = 0.023) independent of visceral adiposity. Conclusion: Patients with NAFLD are at increased risk for coronary atherosclerosis independent of classical coronary risk factors, including visceral adiposity. These data suggest that NAFLD might be an independent risk factor for coronary artery disease. (HEPATOLOGY 2012) |
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| AbstractList | Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim of this study was to investigate whether NAFLD was associated with coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis independent of computed tomography (CT)‐measured visceral adiposity. Out of 5,648 subjects who visited one of our health screening centers between 2003 and 2008, we enrolled 4,023 subjects (mean age, 56.9 ± 9.4 years; 60.7% males) without known liver disease or a history of ischemic heart disease. CAC score was evaluated using the Agatston method. On univariate analysis, the presence of CAC (score >0) was significantly associated with age, sex, body mass index, aspartate aminotransferase, alanine aminotransferase, high‐density lipoprotein cholesterol, triglycerides, and increased risk of diabetes, hypertension, smoking, and NAFLD. Increasing CAC scores (0, <10, 10‐100, ≥100) were associated with higher prevalence of NAFLD (odds ratio [OR], 1.84; 95% confidence interval [CI], 1.61‐2.10; P<0.001). Multivariable ordinal regression analysis was adjusted for traditional risk factors, and CT‐measured visceral adipose tissue area in a subgroup of subjects showed that the increased CAC scores were significantly associated with the presence of NAFLD (OR, 1.28, 95% CI, 1.04‐1.59; P = 0.023) independent of visceral adiposity. Conclusion: Patients with NAFLD are at increased risk for coronary atherosclerosis independent of classical coronary risk factors, including visceral adiposity. These data suggest that NAFLD might be an independent risk factor for coronary artery disease. (HEPATOLOGY 2012) Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim of this study was to investigate whether NAFLD was associated with coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis independent of computed tomography (CT)-measured visceral adiposity. Out of 5,648 subjects who visited one of our health screening centers between 2003 and 2008, we enrolled 4,023 subjects (mean age, 56.9 plus or minus 9.4 years; 60.7% males) without known liver disease or a history of ischemic heart disease. CAC score was evaluated using the Agatston method. On univariate analysis, the presence of CAC (score >0) was significantly associated with age, sex, body mass index, aspartate aminotransferase, alanine aminotransferase, high-density lipoprotein cholesterol, triglycerides, and increased risk of diabetes, hypertension, smoking, and NAFLD. Increasing CAC scores (0, <10, 10-100, greater than or equal to 100) were associated with higher prevalence of NAFLD (odds ratio [OR], 1.84; 95% confidence interval [CI], 1.61-2.10; P<0.001). Multivariable ordinal regression analysis was adjusted for traditional risk factors, and CT-measured visceral adipose tissue area in a subgroup of subjects showed that the increased CAC scores were significantly associated with the presence of NAFLD (OR, 1.28, 95% CI, 1.04-1.59; P = 0.023) independent of visceral adiposity. Conclusion: Patients with NAFLD are at increased risk for coronary atherosclerosis independent of classical coronary risk factors, including visceral adiposity. These data suggest that NAFLD might be an independent risk factor for coronary artery disease. (HEPATOLOGY 2012) Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim of this study was to investigate whether NAFLD was associated with coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis independent of computed tomography (CT)-measured visceral adiposity. Out of 5,648 subjects who visited one of our health screening centers between 2003 and 2008, we enrolled 4,023 subjects (mean age, 56.9 ± 9.4 years; 60.7% males) without known liver disease or a history of ischemic heart disease. CAC score was evaluated using the Agatston method. On univariate analysis, the presence of CAC (score >0) was significantly associated with age, sex, body mass index, aspartate aminotransferase, alanine aminotransferase, high-density lipoprotein cholesterol, triglycerides, and increased risk of diabetes, hypertension, smoking, and NAFLD. Increasing CAC scores (0, <10, 10-100, ≥ 100) were associated with higher prevalence of NAFLD (odds ratio [OR], 1.84; 95% confidence interval [CI], 1.61-2.10; P<0.001). Multivariable ordinal regression analysis was adjusted for traditional risk factors, and CT-measured visceral adipose tissue area in a subgroup of subjects showed that the increased CAC scores were significantly associated with the presence of NAFLD (OR, 1.28, 95% CI, 1.04-1.59; P = 0.023) independent of visceral adiposity.UNLABELLEDNonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim of this study was to investigate whether NAFLD was associated with coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis independent of computed tomography (CT)-measured visceral adiposity. Out of 5,648 subjects who visited one of our health screening centers between 2003 and 2008, we enrolled 4,023 subjects (mean age, 56.9 ± 9.4 years; 60.7% males) without known liver disease or a history of ischemic heart disease. CAC score was evaluated using the Agatston method. On univariate analysis, the presence of CAC (score >0) was significantly associated with age, sex, body mass index, aspartate aminotransferase, alanine aminotransferase, high-density lipoprotein cholesterol, triglycerides, and increased risk of diabetes, hypertension, smoking, and NAFLD. Increasing CAC scores (0, <10, 10-100, ≥ 100) were associated with higher prevalence of NAFLD (odds ratio [OR], 1.84; 95% confidence interval [CI], 1.61-2.10; P<0.001). Multivariable ordinal regression analysis was adjusted for traditional risk factors, and CT-measured visceral adipose tissue area in a subgroup of subjects showed that the increased CAC scores were significantly associated with the presence of NAFLD (OR, 1.28, 95% CI, 1.04-1.59; P = 0.023) independent of visceral adiposity.Patients with NAFLD are at increased risk for coronary atherosclerosis independent of classical coronary risk factors, including visceral adiposity. These data suggest that NAFLD might be an independent risk factor for coronary artery disease.CONCLUSIONPatients with NAFLD are at increased risk for coronary atherosclerosis independent of classical coronary risk factors, including visceral adiposity. These data suggest that NAFLD might be an independent risk factor for coronary artery disease. Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim of this study was to investigate whether NAFLD was associated with coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis independent of computed tomography (CT)-measured visceral adiposity. Out of 5,648 subjects who visited one of health screening centers between 2003 and 2008, we enrolled 4,023 (mean age 56.9 ± 9.4 years, 60.7% males) subjects without known liver disease or a history of ischemic heart disease. CAC score was evaluated by the Agatston method. In univariate analyses, the presence of CAC (score >0) was significantly associated with age, sex, body mass index, aspartate aminotransferase, alanine aminotransferase, high-density lipoprotein cholesterol, triglycerides and increased odds of diabetes, hypertension, smoking, and NAFLD. Increasing CAC scores (0, <10, 10-100, ≥100) were associated with higher prevalence of NAFLD (OR 1.84, 95% CI 1.61-2.10, P <0.001). Multivariate ordinal regression analysis adjusted for traditional risk factors, and CT-measured visceral adipose tissue area in a subgroup of subjects showed that the increased CAC scores were significantly associated with the presence of NAFLD (OR 1.28, 95% CI 1.04-1.59, P =0.023) independent of visceral adiposity. Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim of this study was to investigate whether NAFLD was associated with coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis independent of computed tomography (CT)-measured visceral adiposity. Out of 5,648 subjects who visited one of our health screening centers between 2003 and 2008, we enrolled 4,023 subjects (mean age, 56.9 ± 9.4 years; 60.7% males) without known liver disease or a history of ischemic heart disease. CAC score was evaluated using the Agatston method. On univariate analysis, the presence of CAC (score >0) was significantly associated with age, sex, body mass index, aspartate aminotransferase, alanine aminotransferase, high-density lipoprotein cholesterol, triglycerides, and increased risk of diabetes, hypertension, smoking, and NAFLD. Increasing CAC scores (0, <10, 10-100, ≥ 100) were associated with higher prevalence of NAFLD (odds ratio [OR], 1.84; 95% confidence interval [CI], 1.61-2.10; P<0.001). Multivariable ordinal regression analysis was adjusted for traditional risk factors, and CT-measured visceral adipose tissue area in a subgroup of subjects showed that the increased CAC scores were significantly associated with the presence of NAFLD (OR, 1.28, 95% CI, 1.04-1.59; P = 0.023) independent of visceral adiposity. Patients with NAFLD are at increased risk for coronary atherosclerosis independent of classical coronary risk factors, including visceral adiposity. These data suggest that NAFLD might be an independent risk factor for coronary artery disease. |
| Author | Lee, Whal Kim, Yoon Jun Lee, Dong Ho Jeong, Sook Hyang Yoon, Jung-Hwan Park, Eun Ha Kim, W. Ray Larson, Joseph Kim, Won Choi, Su-Yeon Kim, Donghee Therneau, Terry M. Kang, Jin Hwa Lee, Hyo-suk |
| AuthorAffiliation | 1 Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea 3 Department of Radiology, Seoul National University Hospital, Seoul, Korea 4 Department of Radiology, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea 6 Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea 7 Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA 8 Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA 2 Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea 5 Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea |
| AuthorAffiliation_xml | – name: 2 Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea – name: 7 Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA – name: 8 Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA – name: 3 Department of Radiology, Seoul National University Hospital, Seoul, Korea – name: 6 Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea – name: 5 Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea – name: 4 Department of Radiology, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea – name: 1 Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea |
| Author_xml | – sequence: 1 givenname: Donghee surname: Kim fullname: Kim, Donghee email: messmd@chol.com organization: Departments of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea – sequence: 2 givenname: Su-Yeon surname: Choi fullname: Choi, Su-Yeon organization: Departments of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea – sequence: 3 givenname: Eun Ha surname: Park fullname: Park, Eun Ha organization: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 4 givenname: Whal surname: Lee fullname: Lee, Whal organization: Department of Radiology, Seoul National University Hospital, Seoul, Korea – sequence: 5 givenname: Jin Hwa surname: Kang fullname: Kang, Jin Hwa organization: Radiology, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea – sequence: 6 givenname: Won surname: Kim fullname: Kim, Won organization: Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea – sequence: 7 givenname: Yoon Jun surname: Kim fullname: Kim, Yoon Jun organization: Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea – sequence: 8 givenname: Jung-Hwan surname: Yoon fullname: Yoon, Jung-Hwan organization: Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea – sequence: 9 givenname: Sook Hyang surname: Jeong fullname: Jeong, Sook Hyang organization: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 10 givenname: Dong Ho surname: Lee fullname: Lee, Dong Ho organization: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 11 givenname: Hyo-suk surname: Lee fullname: Lee, Hyo-suk organization: Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea – sequence: 12 givenname: Joseph surname: Larson fullname: Larson, Joseph organization: Divisions of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 13 givenname: Terry M. surname: Therneau fullname: Therneau, Terry M. organization: Divisions of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 14 givenname: W. Ray surname: Kim fullname: Kim, W. Ray organization: Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota |
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| Keywords | Calcification Digestive diseases Hepatic disease Non alcoholic steatohepatitis Coronary artery Gastroenterology |
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| Notes | ArticleID:HEP25593 ark:/67375/WNG-VKFK8DJQ-C The funding organizations had no role in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript. Supported by grant 04-2009-055 from the Seoul National University Hospital Research Fund. Potential conflict of interest: Nothing to report. istex:A7ECA12B0FFF9724DA0AAD0965ACD869A419E26D Supported by grant 04‐2009‐055 from the Seoul National University Hospital Research Fund. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Dong Ho Lee: dhljohn@yahoo.co.kr Won Kim: wonshiri@yahoo.com Donghee Kim: messmd@chol.com Whal Lee: leew@radiol.snu.ac.kr Jin Hwa Kang: peacesta@paran.com Su-Yeon Choi: sychoi9@yahoo.co.kr Park Eun Ha: galaxyeh@naver.com Sook Hyang Jeong: jsh@snubh.org Yoon Jun Kim: yoonjun@snu.ac.kr Jung-Hwan Yoon: yoonjh@snu.ac.kr Hyo-suk Lee: hsleemd@snu.ac.kr W. Ray Kim: kim.woong@mayo.edu Terry M. Therneau: therneau.terry@mayo.edu Joseph Larson: larson.joseph@mayo.edu |
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| SubjectTerms | Age Distribution Aged Atherosclerosis Biological and medical sciences Calcification Calcinosis - diagnostic imaging Calcinosis - epidemiology Cardiovascular disease Cholesterol Confidence intervals Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary vessels Cross-Sectional Studies Diabetes Fatty Liver - diagnostic imaging Fatty Liver - epidemiology Female Gastroenterology. Liver. Pancreas. Abdomen Health risk assessment Hepatology Humans Intra-Abdominal Fat - diagnostic imaging Liver diseases Liver. Biliary tract. Portal circulation. Exocrine pancreas Logistic Models Male Medical sciences Middle Aged Multivariate Analysis Non-alcoholic Fatty Liver Disease Other diseases. Semiology Prevalence Radiography Retrospective Studies Risk Factors Sex Distribution Ultrasonography |
| Title | Nonalcoholic fatty liver disease is associated with coronary artery calcification |
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