Association between HLA‐B1502 Allele and Antiepileptic Drug‐Induced Cutaneous Reactions in Han Chinese

• Published in: Epilepsia (Copenhagen) Vol. 48; no. 5; pp. 1015 - 1018
• Main Authors: Man, Celeste B.L., Kwan, Patrick, Baum, Larry, Yu, Evelyn, Lau, K.M., Cheng, Alice S.H., Ng, Margaret H.L.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.05.2007; Blackwell
• Subjects: Adolescent; Adult; Alleles; Anticonvulsants - adverse effects; Anticonvulsants - therapeutic use; Anticonvulsants. Antiepileptics. Antiparkinson agents; Antiepileptic drugs; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Carbamazepine - adverse effects; Carbamazepine - therapeutic use; Case-Control Studies; Child; Cutaneous reactions; Drug Eruptions - ethnology; Drug Eruptions - etiology; Drug Eruptions - genetics; Drug Hypersensitivity - ethnology; Drug Hypersensitivity - genetics; Drug toxicity and drugs side effects treatment; Epilepsy - drug therapy; Epilepsy - ethnology; Epilepsy - genetics; Female; Genetic Predisposition to Disease - ethnology; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; HLA; HLA-B Antigens - genetics; HLA-B15 Antigen; Hong Kong; Humans; Male; Medical sciences; Middle Aged; Miscellaneous (drug allergy, mutagens, teratogens...); Nervous system (semeiology, syndromes); Neurology; Neuropharmacology; Pharmacogenetics; Pharmacology. Drug treatments; Phenytoin - adverse effects; Phenytoin - therapeutic use; Polymorphism, Genetic; Rash; Stevens-Johnson Syndrome - chemically induced; Stevens-Johnson Syndrome - ethnology; Stevens-Johnson Syndrome - genetics; Stevens‐Johnson syndrome; Triazines - adverse effects; Triazines - therapeutic use; Hong Kong; Bullous dermatosis; HLA-System; HLA-Cutaneous reactions-Antiepileptic drugs-Rash-Stevens-Johnson syndrome; Eye disease; Skin disease; Nervous system diseases; Stomatology; Epilepsy; Central nervous system disease; Anticonvulsant; Stevens Johnson syndrome; Cerebral disorder

A previous study conducted in Taiwan found a 100% association between HLA‐B*1502 allele and carbamazepine‐induced Stevens‐Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine‐tolerant subjects (odds ratio = 2,504). We examined this association...