Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations

• Published in: The journal of clinical endocrinology and metabolism Vol. 101; no. 5; pp. 2226 - 2234
• Main Authors: Nielson, Carrie M., Jones, Kerry S., Chun, Rene F., Jacobs, Jon M., Wang, Ying, Hewison, Martin, Adams, John S., Swanson, Christine M., Lee, Christine G., Vanderschueren, Dirk, Pauwels, Steven, Prentice, Ann, Smith, Richard D., Shi, Tujin, Gao, Yuqian, Schepmoes, Athena A., Zmuda, Joseph M., Lapidus, Jodi, Cauley, Jane A., Bouillon, Roger, Schoenmakers, Inez, Orwoll, Eric S.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2016; Copyright by The Endocrine Society; Endocrine Society
• Subjects: 25-Hydroxyvitamin D; Adult; African Americans; Aged; Black or African American; Black People; Cross-Sectional Studies; Genotypes; Humans; Male; Medical research; Original; Osteoporosis; Proteomics; Race; Racial differences; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D-Binding Protein - blood; White People; United States > US

Context:Total 25-hydroxyvitamin D (25OHD) is a marker of vitamin D status and is lower in African Americans than in whites. Whether this difference holds for free 25OHOD (f25OHD) is unclear, considering reported genetic-racial differences in vitamin D binding protein (DBP) used to calculate f25OHD.O...