CX3CL1 induces cell migration and invasion through ICAM‐1 expression in oral squamous cell carcinoma cells

• Published in: Journal of Cellular and Molecular Medicine Vol. 27; no. 11; pp. 1509 - 1522
• Main Authors: Wu, Chia‐Yu, Peng, Pei‐Wen, Renn, Ting‐Yi, Lee, Chia‐Jung, Chang, Tsung‐Ming, Wei, Augusta I‐Chin, Liu, Ju‐Fang
• Format: Journal Article
• Language: English
• Published: England Wiley 01.06.2023; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Activator protein 1; Antibodies; c-Jun protein; Carcinoma, Squamous Cell; Carcinoma, Squamous Cell - pathology; Cell adhesion; Cell adhesion & migration; Cell culture; Cell Line, Tumor; Cell migration; Cell Movement; Chemokine CX3CL1; Chemokine CX3CL1 - genetics; Chemokine CX3CL1 - metabolism; Chemokines; CX3CL1; CX3CR1 protein; Experiments; Gene expression; Head and Neck Neoplasms; human oral squamous cell carcinoma (OSCC); Humans; ICAM‐1; Intercellular Adhesion Molecule-1; Intercellular Adhesion Molecule-1 - genetics; Intercellular Adhesion Molecule-1 - metabolism; Kinases; Lung cancer; Medical prognosis; Metastases; Metastasis; Molecular modelling; Monoclonal antibodies; Mouth Neoplasms; Mouth Neoplasms - pathology; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; Original; Original Articles; Phosphorylation; PLCβ/PKCα/c‐Src pathway tumour motility; Prognosis; Protein kinase C; Protein Kinase C-alpha; Proteins; RNA, Small Interfering; RNA, Small Interfering - genetics; RNA, Small Interfering - pharmacology; Signal transduction; siRNA; Software; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck; Src protein; Transcription factors; Tumorigenesis; Tumors; ICAM-1; human oral squamous cell carcinoma (OSCC); CX3CL1; PLCβ/PKCα/c-Src pathway tumour motility

Human oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C‐X3‐C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses...