CX3CL1 induces cell migration and invasion through ICAM‐1 expression in oral squamous cell carcinoma cells

Human oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C‐X3‐C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses...

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Published inJournal of Cellular and Molecular Medicine Vol. 27; no. 11; pp. 1509 - 1522
Main Authors Wu, Chia‐Yu, Peng, Pei‐Wen, Renn, Ting‐Yi, Lee, Chia‐Jung, Chang, Tsung‐Ming, Wei, Augusta I‐Chin, Liu, Ju‐Fang
Format Journal Article
LanguageEnglish
Published England Wiley 01.06.2023
John Wiley & Sons, Inc
John Wiley and Sons Inc
Subjects
Activator protein 1
Antibodies
c-Jun protein
Carcinoma, Squamous Cell
Carcinoma, Squamous Cell - pathology
Cell adhesion
Cell adhesion & migration
Cell culture
Cell Line, Tumor
Cell migration
Cell Movement
Chemokine CX3CL1
Chemokine CX3CL1 - genetics
Chemokine CX3CL1 - metabolism
Chemokines
CX3CL1
CX3CR1 protein
Experiments
Gene expression
Head and Neck Neoplasms
human oral squamous cell carcinoma (OSCC)
Humans
ICAM‐1
Intercellular Adhesion Molecule-1
Intercellular Adhesion Molecule-1 - genetics
Intercellular Adhesion Molecule-1 - metabolism
Kinases
Lung cancer
Medical prognosis
Metastases
Metastasis
Molecular modelling
Monoclonal antibodies
Mouth Neoplasms
Mouth Neoplasms - pathology
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
Original
Original Articles
Phosphorylation
PLCβ/PKCα/c‐Src pathway tumour motility
Prognosis
Protein kinase C
Protein Kinase C-alpha
Proteins
RNA, Small Interfering
RNA, Small Interfering - genetics
RNA, Small Interfering - pharmacology
Signal transduction
siRNA
Software
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck
Src protein
Transcription factors
Tumorigenesis
Tumors
ICAM-1
human oral squamous cell carcinoma (OSCC)
CX3CL1
PLCβ/PKCα/c-Src pathway tumour motility
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Abstract Human oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C‐X3‐C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses related to cancer metastasis, including cell movement, migration and invasion in tumour cells. However, CX3CL1 controls the migration ability, and its molecular mechanism in OSCC remains unknown. The present study confirmed that CX3CL1 increased cell movement, migration and invasion. The CX3CL1‐induced cell motility is upregulated through intercellular adhesion molecule‐1 (ICAM‐1) expression in OSCC cells. These effects were significantly suppressed when OSCC cells were pre‐treated with CX3CR1 monoclonal antibody (mAb) and small‐interfering RNA (siRNA). The CX3CL1‐CX3CR1 axis activates promoted PLCβ/PKCα/c‐Src phosphorylation. Furthermore, CX3CL1 enhanced activator protein‐1 (AP‐1) activity. The CX3CR1 mAb and PLCβ, PKCα, c‐Src inhibitors reduced CX3CL1‐induced c‐Jun phosphorylation, c‐Jun translocation into the nucleus and c‐Jun binding to the ICAM‐1 promoter. The present results reveal that CX3CL1 induces the migration of OSCC cells by promoting ICAM‐1 expression through the CX3CR1 and the PLCβ/PKCα/c‐Src signal pathway, suggesting that CX3CL1‐CX3CR1‐mediated signalling is correlated with tumour motility and appealed to be a precursor for prognosis in human OSCC.
AbstractList Human oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C‐X3‐C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses related to cancer metastasis, including cell movement, migration and invasion in tumour cells. However, CX3CL1 controls the migration ability, and its molecular mechanism in OSCC remains unknown. The present study confirmed that CX3CL1 increased cell movement, migration and invasion. The CX3CL1‐induced cell motility is upregulated through intercellular adhesion molecule‐1 (ICAM‐1) expression in OSCC cells. These effects were significantly suppressed when OSCC cells were pre‐treated with CX3CR1 monoclonal antibody (mAb) and small‐interfering RNA (siRNA). The CX3CL1‐CX3CR1 axis activates promoted PLCβ/PKCα/c‐Src phosphorylation. Furthermore, CX3CL1 enhanced activator protein‐1 (AP‐1) activity. The CX3CR1 mAb and PLCβ, PKCα, c‐Src inhibitors reduced CX3CL1‐induced c‐Jun phosphorylation, c‐Jun translocation into the nucleus and c‐Jun binding to the ICAM‐1 promoter. The present results reveal that CX3CL1 induces the migration of OSCC cells by promoting ICAM‐1 expression through the CX3CR1 and the PLCβ/PKCα/c‐Src signal pathway, suggesting that CX3CL1‐CX3CR1‐mediated signalling is correlated with tumour motility and appealed to be a precursor for prognosis in human OSCC.
Human oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C-X3-C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses related to cancer metastasis, including cell movement, migration and invasion in tumour cells. However, CX3CL1 controls the migration ability, and its molecular mechanism in OSCC remains unknown. The present study confirmed that CX3CL1 increased cell movement, migration and invasion. The CX3CL1-induced cell motility is upregulated through intercellular adhesion molecule-1 (ICAM-1) expression in OSCC cells. These effects were significantly suppressed when OSCC cells were pre-treated with CX3CR1 monoclonal antibody (mAb) and small-interfering RNA (siRNA). The CX3CL1-CX3CR1 axis activates promoted PLCβ/PKCα/c-Src phosphorylation. Furthermore, CX3CL1 enhanced activator protein-1 (AP-1) activity. The CX3CR1 mAb and PLCβ, PKCα, c-Src inhibitors reduced CX3CL1-induced c-Jun phosphorylation, c-Jun translocation into the nucleus and c-Jun binding to the ICAM-1 promoter. The present results reveal that CX3CL1 induces the migration of OSCC cells by promoting ICAM-1 expression through the CX3CR1 and the PLCβ/PKCα/c-Src signal pathway, suggesting that CX3CL1-CX3CR1-mediated signalling is correlated with tumour motility and appealed to be a precursor for prognosis in human OSCC.Human oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C-X3-C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses related to cancer metastasis, including cell movement, migration and invasion in tumour cells. However, CX3CL1 controls the migration ability, and its molecular mechanism in OSCC remains unknown. The present study confirmed that CX3CL1 increased cell movement, migration and invasion. The CX3CL1-induced cell motility is upregulated through intercellular adhesion molecule-1 (ICAM-1) expression in OSCC cells. These effects were significantly suppressed when OSCC cells were pre-treated with CX3CR1 monoclonal antibody (mAb) and small-interfering RNA (siRNA). The CX3CL1-CX3CR1 axis activates promoted PLCβ/PKCα/c-Src phosphorylation. Furthermore, CX3CL1 enhanced activator protein-1 (AP-1) activity. The CX3CR1 mAb and PLCβ, PKCα, c-Src inhibitors reduced CX3CL1-induced c-Jun phosphorylation, c-Jun translocation into the nucleus and c-Jun binding to the ICAM-1 promoter. The present results reveal that CX3CL1 induces the migration of OSCC cells by promoting ICAM-1 expression through the CX3CR1 and the PLCβ/PKCα/c-Src signal pathway, suggesting that CX3CL1-CX3CR1-mediated signalling is correlated with tumour motility and appealed to be a precursor for prognosis in human OSCC.
Author Tsung‐Ming Chang
Ju‐Fang Liu
Pei‐Wen Peng
Chia‐Yu Wu
Augusta I‐Chin Wei
Chia‐Jung Lee
Ting‐Yi Renn
AuthorAffiliation 1 School of Dental Technology, College of Oral Medicine Taipei Medical University Taipei City Taiwan
6 Institute of Physiology, School of Medicine National Yang Ming Chiao Tung University Taipei City Taiwan
2 Division of Oral and Maxillofacial Surgery, Department of Dentistry Taipei Medical University Hospital Taipei City Taiwan
9 Department of Medical Research China Medical University Hospital, China Medical University Taichung City Taiwan
4 Department of Otolaryngology Head and Neck Surgery Shin‐Kong Wu‐Ho‐Su Memorial Hospital Taipei City Taiwan
5 School of Medicine Fu‐Jen Catholic University Taipei City Taiwan
7 Translational Medicine Center Shin‐Kong Wu Ho‐Su Memorial Hospital Taipei City Taiwan
8 School of Oral Hygiene, College of Oral Medicine Taipei Medical University Taipei City Taiwan
3 Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan
AuthorAffiliation_xml – name: 1 School of Dental Technology, College of Oral Medicine Taipei Medical University Taipei City Taiwan
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Keywords ICAM-1
human oral squamous cell carcinoma (OSCC)
CX3CL1
PLCβ/PKCα/c-Src pathway tumour motility
Language English
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SSID ssib004298280
ssj0036139
ssib044743690
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Snippet Human oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis....
SourceID pubmedcentral
proquest
pubmed
crossref
wiley
nii
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1509
SubjectTerms Activator protein 1
Antibodies
c-Jun protein
Carcinoma, Squamous Cell
Carcinoma, Squamous Cell - pathology
Cell adhesion
Cell adhesion & migration
Cell culture
Cell Line, Tumor
Cell migration
Cell Movement
Chemokine CX3CL1
Chemokine CX3CL1 - genetics
Chemokine CX3CL1 - metabolism
Chemokines
CX3CL1
CX3CR1 protein
Experiments
Gene expression
Head and Neck Neoplasms
human oral squamous cell carcinoma (OSCC)
Humans
ICAM‐1
Intercellular Adhesion Molecule-1
Intercellular Adhesion Molecule-1 - genetics
Intercellular Adhesion Molecule-1 - metabolism
Kinases
Lung cancer
Medical prognosis
Metastases
Metastasis
Molecular modelling
Monoclonal antibodies
Mouth Neoplasms
Mouth Neoplasms - pathology
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
Original
Original Articles
Phosphorylation
PLCβ/PKCα/c‐Src pathway tumour motility
Prognosis
Protein kinase C
Protein Kinase C-alpha
Proteins
RNA, Small Interfering
RNA, Small Interfering - genetics
RNA, Small Interfering - pharmacology
Signal transduction
siRNA
Software
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck
Src protein
Transcription factors
Tumorigenesis
Tumors
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Title CX3CL1 induces cell migration and invasion through ICAM‐1 expression in oral squamous cell carcinoma cells
URI https://cir.nii.ac.jp/crid/1870865117779433472
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjcmm.17750
https://www.ncbi.nlm.nih.gov/pubmed/37082943
https://www.proquest.com/docview/2822668764
https://www.proquest.com/docview/2805030660
https://pubmed.ncbi.nlm.nih.gov/PMC10243164
Volume 27
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