Stem Cell-Associated Proteins and Extracellular Matrix Composition of the Human Atrioventricular Junction

• Published in: Cells (Basel, Switzerland) Vol. 13; no. 24; p. 2048
• Main Authors: Thorsell, Annika, Sjölin, Linnéa, Berger, Evelin, Jeppsson, Anders, Oldfors, Anders, Rotter Sopasakis, Victoria, Vukusic, Kristina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2024; MDPI
• Subjects: Adult; Aged; atrioventricular junction; Biomarkers; Biomarkers - metabolism; Biopsy; Blood & organ donations; cardiac regeneration; Cardiomyocytes; Cell Biology; Cell Differentiation; Cellbiologi; Chromatography; Extracellular matrix; Extracellular Matrix - metabolism; Female; Gene expression; Genes; global quantitative proteomics; Heart; Heart Ventricles - cytology; Heart Ventricles - metabolism; Histology; Humans; Hypoxia; Immunohistochemistry; Invoices; Male; Microenvironments; Middle Aged; mRNA-seq; Particle size; Peptides; Protein composition; Proteins; Proteomics; Proteomics - methods; RNA; RNA sequencing; Signal transduction; stem cell niche; Stem cells; Stem Cells - cytology; Stem Cells - metabolism; Transforming growth factor-b; Transforming growth factors; Wnt protein; United States; Sweden; Massachusetts; United States > US; cardiomyocytes; cardiac regeneration; global quantitative proteomics; stem cell niche; mRNA-seq; atrioventricular junction; extracellular matrix; heart

The human heart regenerates slowly through life, but how new cells are generated is mostly unknown. The atrioventricular junction (AVj) has been indicated as a potential stem cell niche region. Little is known about the protein composition of the human AVj. To map the extracellular matrix (ECM) and...