Association of intronic single-nucleotide polymorphisms in the EMILIN1 gene with essential hypertension in a Chinese population

• Published in: Journal of human hypertension Vol. 26; no. 9; pp. 553 - 561
• Main Authors: Oh, V M S, Chua, B-M, Heng, C-K, Yeo, S-B, Yim, O-S, Yap, E P H
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2012; Nature Publishing Group
• Subjects: 631/208/726/649; 692/699/75/243; 692/700/478/174; Adult; Alleles; Arterial hypertension. Arterial hypotension; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Care and treatment; Case-Control Studies; Chinese; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Demographic aspects; Diabetes mellitus; Elastin; Elastin microfibril interface located protein; Epidemiology; Essential Hypertension; Exons; Female; Gene Frequency; Genetic aspects; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes; Health Administration; Health aspects; Humans; Hypertension; Hypertension - genetics; Identification and classification; Introns; Introns - genetics; Linkage Disequilibrium; Male; Medical sciences; Medicine; Medicine & Public Health; Membrane Glycoproteins - genetics; Microfibrils; Middle Aged; original-article; Polymorphism, Single Nucleotide; Population studies; Public Health; Risk factors; Risk groups; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Singapore; essential hypertension; blood pressure; Chinese; haplotype; elastin microfibril interfacer 1; genetic polymorphism; Hypertension; Elastin; Cardiovascular disease; Arterial pressure; Blood pressure; Single nucleotide polymorphism; Haplotype

Studies in mice suggest that the elastin microfibril interfacer-1 gene ( EMILIN1), the gene encoding elastin microfibril interfacer-1 protein, contributes to the pathogenesis of essential hypertension (EH) in humans. EMILIN1 in part maintains elastic fibres in vessel walls, and hence peripheral arte...