Adiponectin Exerts Neurotrophic Effects on Dendritic Arborization, Spinogenesis, and Neurogenesis of the Dentate Gyrus of Male Mice

The hippocampus, a brain region critical for learning, memory and emotional processing, maintains its capacity to undergo structural plasticity throughout life. Hippocampal structural plasticity can be modulated by a number of intrinsic and extrinsic factors. This study investigated the effects of a...

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Published inEndocrinology (Philadelphia) Vol. 157; no. 7; pp. 2853 - 2869
Main Authors Zhang, Di, Wang, Xuezhen, Lu, Xin-Yun
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 01.07.2016
Endocrine Society
Subjects
Adiponectin
Adiponectin - genetics
Adiponectin - metabolism
Adiponectin - pharmacology
Animals
Cell differentiation
Cell Differentiation - drug effects
Cell Differentiation - genetics
Cell proliferation
Cell Proliferation - drug effects
Cell Proliferation - genetics
Cells (biology)
Dendrites - drug effects
Dendrites - metabolism
Dendritic branching
Dendritic plasticity
Dendritic spines
Dendritic Spines - drug effects
Dendritic Spines - metabolism
Dendritic structure
Dentate gyrus
Dentate Gyrus - drug effects
Dentate Gyrus - metabolism
Granular materials
Granule cells
Hippocampal plasticity
Hippocampus
Male
Mice
Mice, Knockout
Neural stem cells
Neural Stem Cells - drug effects
Neural Stem Cells - metabolism
Neurogenesis
Neurogenesis - drug effects
Neurogenesis - genetics
Neurons
Neuroplasticity
Original Research
Plastic properties
Plasticity
Progenitor cells
Spine
Online AccessGet full text

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Abstract The hippocampus, a brain region critical for learning, memory and emotional processing, maintains its capacity to undergo structural plasticity throughout life. Hippocampal structural plasticity can be modulated by a number of intrinsic and extrinsic factors. This study investigated the effects of adiponectin, an adipocyte-derived hormone, on dendritic growth, arborization, and spinogenesis in mature granule neurons of the hippocampal dentate gyrus generated during embryonic (early-born) or early postnatal (late-born) stages. We found that adiponectin deficiency reduced dendritic length, branching and spine density of granule neurons. The reduction was more evident in early-born granule neurons than in late-born granule neurons. Intracerebroventricular infusion of adiponectin for 1 week increased of dendritic spines and arbor complexity in late-born granule neurons. Moreover, adiponectin deficiency decreased the production of adult-born new granule neurons through suppressing neural progenitor cell proliferation and differentiation, whereas intracerebroventricular adiponectin infusion increased the proliferation of neural progenitor cells in adult dentate gyrus. These results suggest that adiponectin plays an important role in dendritic spine remodeling and neurogenesis in the dentate gyrus.
AbstractList The hippocampus, a brain region critical for learning, memory and emotional processing, maintains its capacity to undergo structural plasticity throughout life. Hippocampal structural plasticity can be modulated by a number of intrinsic and extrinsic factors. This study investigated the effects of adiponectin, an adipocyte-derived hormone, on dendritic growth, arborization, and spinogenesis in mature granule neurons of the hippocampal dentate gyrus generated during embryonic (early-born) or early postnatal (late-born) stages. We found that adiponectin deficiency reduced dendritic length, branching and spine density of granule neurons. The reduction was more evident in early-born granule neurons than in late-born granule neurons. Intracerebroventricular infusion of adiponectin for 1 week increased of dendritic spines and arbor complexity in late-born granule neurons. Moreover, adiponectin deficiency decreased the production of adult-born new granule neurons through suppressing neural progenitor cell proliferation and differentiation, whereas intracerebroventricular adiponectin infusion increased the proliferation of neural progenitor cells in adult dentate gyrus. These results suggest that adiponectin plays an important role in dendritic spine remodeling and neurogenesis in the dentate gyrus.
Author Wang, Xuezhen
Lu, Xin-Yun
Zhang, Di
Author_xml – sequence: 1
  givenname: Di
  surname: Zhang
  fullname: Zhang, Di
  organization: 1Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229
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  givenname: Xuezhen
  surname: Wang
  fullname: Wang, Xuezhen
  organization: 1Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229
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  givenname: Xin-Yun
  surname: Lu
  fullname: Lu, Xin-Yun
  email: lux3@uthscsa.edu
  organization: 1Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229
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Snippet The hippocampus, a brain region critical for learning, memory and emotional processing, maintains its capacity to undergo structural plasticity throughout...
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SubjectTerms Adiponectin
Adiponectin - genetics
Adiponectin - metabolism
Adiponectin - pharmacology
Animals
Cell differentiation
Cell Differentiation - drug effects
Cell Differentiation - genetics
Cell proliferation
Cell Proliferation - drug effects
Cell Proliferation - genetics
Cells (biology)
Dendrites - drug effects
Dendrites - metabolism
Dendritic branching
Dendritic plasticity
Dendritic spines
Dendritic Spines - drug effects
Dendritic Spines - metabolism
Dendritic structure
Dentate gyrus
Dentate Gyrus - drug effects
Dentate Gyrus - metabolism
Granular materials
Granule cells
Hippocampal plasticity
Hippocampus
Male
Mice
Mice, Knockout
Neural stem cells
Neural Stem Cells - drug effects
Neural Stem Cells - metabolism
Neurogenesis
Neurogenesis - drug effects
Neurogenesis - genetics
Neurons
Neuroplasticity
Original Research
Plastic properties
Plasticity
Progenitor cells
Spine
Title Adiponectin Exerts Neurotrophic Effects on Dendritic Arborization, Spinogenesis, and Neurogenesis of the Dentate Gyrus of Male Mice
URI https://www.ncbi.nlm.nih.gov/pubmed/27187175
https://www.proquest.com/docview/3130712752
https://www.proquest.com/docview/1891882013
https://pubmed.ncbi.nlm.nih.gov/PMC4929553
Volume 157
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