Pathogenesis of flavivirus encephalitis
Within the flavivirus family, viruses that cause natural infections of the central nervous system (CNS) principally include members of the Japanese encephalitis virus (JEV) serogroup and the tick-borne encephalitis virus (TBEV) serocomplex. The pathogenesis of diseases involves complex interactions...
Saved in:
Published in | Advances in Virus Research Vol. 60; pp. 273 - 342 |
---|---|
Main Authors | , |
Format | Book Chapter Journal Article |
Language | English |
Published |
United States
Elsevier Science & Technology
2003
Elsevier Inc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Within the flavivirus family, viruses that cause natural infections of the central nervous system (CNS) principally include members of the Japanese encephalitis virus (JEV) serogroup and the tick-borne encephalitis virus (TBEV) serocomplex. The pathogenesis of diseases involves complex interactions of viruses, which differ in neurovirulence potential, and a number of host factors, which govern susceptibility to infection and the capacity to mount effective antiviral immune responses both in the periphery and within the CNS. This chapter summarizes progress in the field of flavivirus neuropathogenesis. Mosquito-borne and tickborne viruses are considered together. Flavivirus neuropathogenesis involves both neuroinvasiveness (capacity to enter the CNS) and neurovirulence (replication within the CNS), both of which can be manipulated experimentally. Neuronal injury as a result of bystander effects may be a factor during flavivirus neuropathogenesis given that microglial activation and elaboration of inflammatory mediators, including IL-1β and TNF-α, occur in the CNS during these infections and may accompany the production of nitric oxide and peroxynitrite, which can cause neurotoxicity. |
---|---|
AbstractList | Within the flavivirus family, viruses that cause natural infections of the central nervous system (CNS) principally include members of the Japanese encephalitis virus (JEV) serogroup and the tick-borne encephalitis virus (TBEV) serocomplex. The pathogenesis of diseases involves complex interactions of viruses, which differ in neurovirulence potential, and a number of host factors, which govern susceptibility to infection and the capacity to mount effective antiviral immune responses both in the periphery and within the CNS. This chapter summarizes progress in the field of flavivirus neuropathogenesis. Mosquito-borne and tickborne viruses are considered together. Flavivirus neuropathogenesis involves both neuroinvasiveness (capacity to enter the CNS) and neurovirulence (replication within the CNS), both of which can be manipulated experimentally. Neuronal injury as a result of bystander effects may be a factor during flavivirus neuropathogenesis given that microglial activation and elaboration of inflammatory mediators, including IL-1β and TNF-α, occur in the CNS during these infections and may accompany the production of nitric oxide and peroxynitrite, which can cause neurotoxicity. |
Author | Diamond, Michael S Chambers, Thomas J |
Author_xml | – sequence: 1 givenname: Thomas J surname: Chambers fullname: Chambers, Thomas J organization: Department of Molecular Microbiology and Immunology St. Louis University Health Sciences Center, School of Medicine St. Louis, Missouri 63104, USA – sequence: 2 givenname: Michael S surname: Diamond fullname: Diamond, Michael S organization: Department of Molecular Microbiology, Medicine, Pathology, and Immunology Washington University School of Medicine St. Louis, Missouri 63110, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/14689697$$D View this record in MEDLINE/PubMed |
BookMark | eNqFUk1vEzEUNFCgSeEngHIqcFh4_rYvoKriS6oEEnB-8jpvG8Nmna43kfj3OG2ogAunObyZ0WjezNnRkAdi7AmHlxy4efUFwOhGamGfg3xhAMA16g6bVwTlpRPyLptxrW3jpPf36oELkN4Z0Edsdit-wGbKGjDWaHXM5qV8BxDWGf6QHXNlnDfeztizz2Fa5UsaqKSyyN2i68Mu7dK4LQsaIm1WoU9TKo_Y_S70hR4f8IR9e_f26_mH5uLT-4_nZxdN1EpODQHvnHJtEFa3XFgpgw3LaKDTS-lV23qntYpUUYrWh04Fb0zoLG9FdNrLE_b6xnezbde0jDRMY-hxM6Z1GH9iDgn_vgxphZd5h1aAUNpVg9ODwZivtlQmXKcSqe_DQHlb0PLaiqjJ_kfkDoys7Vfi0z8j3Wb5XWIliH-cqM35xyFhXIXNRGNB4Sufo5Uo3D7nmxsR1TZ3iUYsMe0bX6aR4oTLnJAD7heB14vA_VMRJF4vApX8BRWyorI |
CitedBy_id | crossref_primary_10_1128_JVI_00789_08 crossref_primary_10_1186_s12985_016_0658_4 crossref_primary_10_1134_S1063774520060267 crossref_primary_10_1007_PL00022204 crossref_primary_10_1016_j_trstmh_2008_01_024 crossref_primary_10_1089_vim_2018_0075 crossref_primary_10_1586_14787210_3_6_931 crossref_primary_10_1007_s13311_016_0443_5 crossref_primary_10_1042_BJ20100074 crossref_primary_10_1371_journal_ppat_1000614 crossref_primary_10_1016_j_vaccine_2009_03_007 crossref_primary_10_3389_fcimb_2017_00276 crossref_primary_10_1371_journal_pone_0155889 crossref_primary_10_3390_v10060329 crossref_primary_10_1016_j_onehlt_2023_100525 crossref_primary_10_1371_journal_ppat_1006764 crossref_primary_10_3390_pathogens9010048 crossref_primary_10_1369_jhc_2009_954180 crossref_primary_10_1128_spectrum_02192_23 crossref_primary_10_1016_j_virol_2005_07_013 crossref_primary_10_1128_JVI_00458_08 crossref_primary_10_1080_13550280500384982 crossref_primary_10_1016_j_virusres_2011_09_040 crossref_primary_10_1177_0300985810372507 crossref_primary_10_2478_fv_2024_0002 crossref_primary_10_1016_j_tmaid_2010_06_004 crossref_primary_10_3390_v15122416 crossref_primary_10_3390_insects15060446 crossref_primary_10_1016_j_antiviral_2019_01_014 crossref_primary_10_1099_vir_0_81306_0 crossref_primary_10_2174_1570163816666190715114741 crossref_primary_10_1042_BJ20061136 crossref_primary_10_1016_j_tracli_2017_05_005 crossref_primary_10_1016_j_virusres_2005_04_007 crossref_primary_10_1002_eji_200737196 crossref_primary_10_1007_s40475_020_00200_7 crossref_primary_10_1128_JVI_00489_06 crossref_primary_10_1146_annurev_virology_092917_043439 crossref_primary_10_1016_j_coviro_2014_12_009 crossref_primary_10_3390_v14061319 crossref_primary_10_1093_jnen_64_6_506 crossref_primary_10_1128_JVI_78_15_8312_8321_2004 crossref_primary_10_1016_j_actatropica_2014_03_028 crossref_primary_10_4167_jbv_2012_42_2_108 crossref_primary_10_3389_fcimb_2020_00244 crossref_primary_10_1186_1743_422X_8_92 crossref_primary_10_1177_0300985815612554 crossref_primary_10_1002_ana_20959 crossref_primary_10_1016_j_onehlt_2023_100506 crossref_primary_10_3390_v4123812 crossref_primary_10_3390_v8090252 crossref_primary_10_1051_vetres_2010039 crossref_primary_10_1128_mbio_00712_23 crossref_primary_10_3390_pathogens12050715 crossref_primary_10_1128_JVI_00197_16 crossref_primary_10_1128_JVI_79_21_13350_13361_2005 crossref_primary_10_4049_jimmunol_181_12_8568 crossref_primary_10_1016_j_ibneur_2022_10_011 crossref_primary_10_1007_s11262_006_0075_7 crossref_primary_10_1089_vim_2006_19_74 crossref_primary_10_3201_eid2407_180059 crossref_primary_10_1017_S0317167100053750 crossref_primary_10_3390_v5112856 crossref_primary_10_1371_journal_pone_0086219 crossref_primary_10_1128_JVI_00314_08 crossref_primary_10_1371_journal_pone_0001171 crossref_primary_10_3390_v13102065 crossref_primary_10_1016_j_micpath_2012_01_003 crossref_primary_10_1038_s41467_023_41600_3 crossref_primary_10_3390_jcm12216859 crossref_primary_10_1016_j_virol_2017_04_012 crossref_primary_10_1016_j_ncl_2008_03_012 crossref_primary_10_3390_pathogens10060748 crossref_primary_10_1128_JVI_00172_08 crossref_primary_10_1128_JVI_02422_06 |
ContentType | Book Chapter Journal Article |
Copyright | 2003 Elsevier Inc. Copyright © 2003 Elsevier Inc. All rights reserved. 2003 Elsevier Inc. |
Copyright_xml | – notice: 2003 Elsevier Inc. – notice: Copyright © 2003 Elsevier Inc. All rights reserved. 2003 Elsevier Inc. |
DBID | FFUUA CGR CUY CVF ECM EIF NPM 7U9 H94 7X8 5PM |
DEWEY | 579.2562 |
DOI | 10.1016/S0065-3527(03)60008-4 |
DatabaseName | ProQuest Ebook Central - Book Chapters - Demo use only Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Virology and AIDS Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts Virology and AIDS Abstracts MEDLINE - Academic |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISBN | 0080493823 9780080493824 |
EISSN | 1557-8399 |
EndPage | 342 |
ExternalDocumentID | 14689697 EBC296891_73_288 S0065352703600084 |
Genre | Journal Article Review |
GroupedDBID | --- --K -~X .GJ 0R~ 23M 3O- 53G 5GY 5RE 8N9 8NA 8NF AAKMA AAXUO AAYSV ABGWT ABMAC ABQQC ACGFS ACXMD ADOJD AENEX AFDAS AFFNX AFOST AFTJW AGAMA AHPSJ AI. ALMA_UNASSIGNED_HOLDINGS ASPBG AVWKF CS3 EBS EJD F5P FDB FEDTE HVGLF HZ~ JDP L7B O9- P2P SBF SDK SES SHL UPT UQL VH1 WH7 X7N XOL ZGI ZKB ~KM 089 20A 38. A4I A4J AABBV AAVWF AZZ BBABE CZZ FFUUA MYL AAHBH AALRI AHMUE AKRWK CGR CUY CVF ECM EIF NPM 7U9 H94 7X8 5PM |
ID | FETCH-LOGICAL-c543t-e01f848ba275b12733a7adc60f5d394bb98554ceb9832b9af4a966af71b2c8593 |
ISBN | 0120398605 9780120398607 |
ISSN | 0065-3527 |
IngestDate | Tue Sep 17 21:14:40 EDT 2024 Sat Aug 17 00:02:47 EDT 2024 Fri Aug 16 10:22:10 EDT 2024 Sat Sep 28 08:28:00 EDT 2024 Sat Oct 05 22:01:40 EDT 2024 Fri Feb 23 02:28:04 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
LCCallNum | QR360.A3eb vol. 60 |
Language | English |
License | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c543t-e01f848ba275b12733a7adc60f5d394bb98554ceb9832b9af4a966af71b2c8593 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1 |
OCLC | 476067654 |
OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7202458 |
PMID | 14689697 |
PQID | EBC296891_73_288 |
PQPubID | 23462 |
PageCount | 70 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7202458 proquest_miscellaneous_71476227 proquest_miscellaneous_18063600 pubmed_primary_14689697 proquest_ebookcentralchapters_296891_73_288 elsevier_sciencedirect_doi_10_1016_S0065_3527_03_60008_4 |
PublicationCentury | 2000 |
PublicationDate | 2003 2003-00-00 20030101 |
PublicationDateYYYYMMDD | 2003-01-01 |
PublicationDate_xml | – year: 2003 text: 2003 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Advances in Virus Research |
PublicationTitleAlternate | Adv Virus Res |
PublicationYear | 2003 |
Publisher | Elsevier Science & Technology Elsevier Inc |
Publisher_xml | – name: Elsevier Science & Technology – name: Elsevier Inc |
SSID | ssj0027861 ssj0000155924 ssib013839347 |
Score | 2.037448 |
SecondaryResourceType | review_article |
Snippet | Within the flavivirus family, viruses that cause natural infections of the central nervous system (CNS) principally include members of the Japanese... |
SourceID | pubmedcentral proquest pubmed elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 273 |
SubjectTerms | Animals Brain - pathology Brain - virology Complement System Proteins - physiology Encephalitis, Arbovirus - etiology Encephalitis, Arbovirus - immunology Encephalitis, Tick-Borne - etiology Encephalitis, Tick-Borne - immunology Flavivirus Flavivirus - pathogenicity Flavivirus Infections - etiology Flavivirus Infections - immunology Humans Immunology Interferon-gamma - biosynthesis Killer Cells, Natural - immunology Macrophages - immunology Virology West Nile virus - pathogenicity |
Title | Pathogenesis of flavivirus encephalitis |
URI | https://dx.doi.org/10.1016/S0065-3527(03)60008-4 http://ebookcentral.proquest.com/lib/SITE_ID/reader.action?docID=296891&ppg=288 https://www.ncbi.nlm.nih.gov/pubmed/14689697 https://search.proquest.com/docview/18063600 https://search.proquest.com/docview/71476227 https://pubmed.ncbi.nlm.nih.gov/PMC7202458 |
Volume | 60 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZoERLiQnku0JIDFaAqJbaT2D621a4KlRCClvZmxU5CI1XZqputVH49M3EemxQO5ZKsHG9kz-eMv7FnxoS8SwVLrDTCp7kFA4XT2DcwE_h5HMFkokTG09rL92t8eBJ-OYvO-hNP6-iSyuza33-NK_kfVKEMcMUo2Tsg270UCuA34AtXQBiuI_I7XGbtAJ5dJNfFdXG1XDjXtm_A5-a_UH0VLvfy5zr8o7pZHRmDSsAV-5fsTDGG8RypeTFcD-Cj9YAuUKXVDTiCRsv0rfmIgbNcydidO9vqQ5ff_5ZqdVb-D-QsPrA2sY3nWm0zsIDQgyLs55N2D5258_pG6ayn-wfwH6moFlxDlTWyJhSoo_t7ez9PZ60qoGA4K95YOi4TGJg-LKyTIjWNjpr8SV0n-gCtT30zPwT8Y9PEAd-4bU-M3WJXeMbxY_IIY088DAqB3myQe1n5hDxw54XePCXvV6Hz5rnXQ-etQveMnMymxweHfnPShW-jkFd-FtBchtIkTESGAqPkiUhSGwd5lHIVGqPQm9BmcOfMqCQPEzBTk1xQwyxmrHtO1st5mb0kHjd5zFJqFRiSQI6lsbEElgusF4ryzEyIbIWgG5LlyJMGoHXv8wfy0yg_HXBdy0-HE7LTCk3XW_mNoKwTykIPgJ2Qt11tUFm4D5WU2Xy50FQGmKUu-HcNQUOYpJmYkBcOEn3pcq-gpSpVrOCJGIDVVcB06cMnZXFep00XDN0M5Ks79eI1edh_ZG_IenW1zDaBhlZmqxmyeD_6fnr0Bwv6g1E |
link.rule.ids | 230,315,785,786,790,799,891,4043,27956,27957,27958 |
linkProvider | Library Specific Holdings |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.title=The+Flaviviruses%3A+Pathogenesis+and+Immunity&rft.atitle=Pathogenesis+of+Flavivirus+Encephalitis&rft.date=2003-01-01&rft.pub=Elsevier+Science+%26+Technology&rft.isbn=9780120398607&rft.volume=60&rft_id=info:doi/10.1016%2FS0065-3527%2803%2960008-4&rft.externalDBID=288&rft.externalDocID=EBC296891_73_288 |
thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Febookcentral.proquest.com%2Fcovers%2F296891-l.jpg |