Polygenic determinants of severe hypertriglyceridemia

• Published in: Human molecular genetics Vol. 17; no. 18; pp. 2894 - 2899
• Main Authors: Wang, Jian, Ban, Matthew R., Zou, Guang Yong, Cao, Henian, Lin, Tim, Kennedy, Brooke A., Anand, Sonia, Yusuf, Salim, Huff, Murray W., Pollex, Rebecca L., Hegele, Robert A.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.09.2008; Oxford Publishing Limited (England)
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adult; Apolipoproteins - genetics; Biological and medical sciences; Case-Control Studies; Disorders of blood lipids. Hyperlipoproteinemia; Female; Fundamental and applied biological sciences. Psychology; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genotype; GTP-Binding Proteins - genetics; Humans; Hypertriglyceridemia - genetics; Intracellular Signaling Peptides and Proteins - genetics; Male; Medical sciences; Metabolic diseases; Middle Aged; Molecular and cellular biology; Multifactorial Inheritance; Multivariate Analysis; N-Acetylgalactosaminyltransferases - genetics; Polypeptide N-acetylgalactosaminyltransferase; Protein Serine-Threonine Kinases - genetics; Triglycerides - blood; White People - genetics; Hypertriglyceridemia; Polygenic; Metabolic diseases; Genetics; Lipids; Hyperlipoproteinemia; Lipoprotein; Dyslipemia; Severe; Triglyceride; Enzymopathy

Recent genome-wide association (GWA) studies have identified new genetic determinants of complex quantitative traits, including plasma triglyceride (TG). We hypothesized that common variants associated with mild TG variation identified in GWA studies would also be associated with severe hypertriglyc...