Office-Based Intraosseous Infiltrations of PRGF as an Effective Treatment for Knee Osteoarthritis: A Retrospective Observational Clinical Study

• Published in: Journal of clinical medicine Vol. 12; no. 13; p. 4512
• Main Authors: Ríos Luna, Antonio, Fahandezh-Saddi Díaz, Homid, Villanueva Martínez, Manuel, Iglesias, Roberto, Prado, Roberto, Padilla, Sabino, Anitua, Eduardo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2023; MDPI
• Subjects: Activities of daily living; Arthritis; Blood platelets; Care and treatment; Clinical medicine; Diagnosis; Evaluation; Growth factors; Injuries; intraosseous; Knee; Knee joint; Leukocytes; Local anesthesia; Observational studies; Osteoarthritis; Pain; Patient outcomes; Patients; Plasma; platelet-rich plasma; Platelet-rich plasma therapy; PRGF; Quality of life; Ultrasonic imaging; Spain; intraosseous; PRGF; platelet-rich plasma; osteoarthritis
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12134512

The aim of this study was to explore and assess office-based ultrasound-guided intraosseous and intra-articular infiltrations of plasma rich in growth factors (PRGF) in patients with moderate and severe knee osteoarthritis (KOA). Seventy-nine patients (30 women and 49 men) with grade 3-4 KOA according to the Kellgren-Lawrence classification participated in the study. All patients were treated with a minimally invasive technique using local anesthesia WALANT (wide-awake local anesthesia no tourniquet) in the ambulatory setting. A PRGF intra-articular infiltration and two intraosseous infiltrations in the tibial plateau and femoral condyle were performed weekly for a total of three sessions. The evaluation of the results was carried out using knee injury and osteoarthritis outcome score (KOOS) at baseline and post-treatment. After a follow-up period of 11 months (median) [interquartile range, 7-14], all the KOOS domains showed statistically significant improvement ( < 0.001). Moreover, 88% of the patients showed a pain reduction of at least 10 points (minimally clinically important improvement) from pre- to post-treatment. Our retrospective study using the in-office procedure of ultrasound-guided combination of intra-articular and intraosseous infiltrations of PRGF is a safe and efficacious approach for the treatment of grade 3-4 knee osteoarthritis.