Endurance exercise training improves endothelium-dependent relaxation in brachial arteries from hypercholesterolemic male pigs

• Published in: Journal of applied physiology (1985) Vol. 99; no. 4; pp. 1412 - 1421
• Main Authors: Woodman, Christopher R, Thompson, Mark A, Turk, James R, Laughlin, M. Harold
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.10.2005; American Physiological Society
• Subjects: Acetylcholine - pharmacology; Animals; Biological and medical sciences; Blood vessels; Brachial Artery - drug effects; Brachial Artery - metabolism; Brachial Artery - physiopathology; Bradykinin - pharmacology; Caveolin 1 - metabolism; Endothelium, Vascular - physiopathology; Exercise; Fundamental and applied biological sciences. Psychology; Hogs; Hypercholesterolemia - physiopathology; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Male; Nitric oxide; Nitric Oxide Synthase Type III - metabolism; Nitroprusside - pharmacology; Physical Conditioning, Animal; Physical Endurance; Superoxide Dismutase - metabolism; Superoxide Dismutase-1; Swine; Swine, Miniature; Vasodilation; Vasodilator Agents - pharmacology; Physical exercise; endothelium-derived hyperpolarizing factor: endothelial nitric oxide synthase; Physical training; Prostaglandin I2; Lipids; Smooth muscle; Male; Hyperlipoproteinemia; Lipoprotein; Relaxation; Endurance; Dyslipemia; Ungulata; vascular smooth muscle; Enzyme; prostacyclin; Brachial artery; Metabolic diseases; Cholesterol; Nitric-oxide synthase; Endothelium; Pig; Vertebrata; Mammalia; Hypercholesterolemia; Nitric oxide; Artiodactyla; Oxidoreductases

Department of Biomedical Sciences, University of Missouri, Columbia, Missouri Submitted 16 March 2005 ; accepted in final form 17 June 2005 We tested the hypothesis that exercise (Ex) training attenuates hypercholesterolemia-induced impairment of endothelium-dependent relaxation (EDR) in brachial (B...