Endurance exercise training improves endothelium-dependent relaxation in brachial arteries from hypercholesterolemic male pigs
Department of Biomedical Sciences, University of Missouri, Columbia, Missouri Submitted 16 March 2005 ; accepted in final form 17 June 2005 We tested the hypothesis that exercise (Ex) training attenuates hypercholesterolemia-induced impairment of endothelium-dependent relaxation (EDR) in brachial (B...
Saved in:
Published in | Journal of applied physiology (1985) Vol. 99; no. 4; pp. 1412 - 1421 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
Am Physiological Soc
01.10.2005
American Physiological Society |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Department of Biomedical Sciences, University of Missouri, Columbia, Missouri
Submitted 16 March 2005
; accepted in final form 17 June 2005
We tested the hypothesis that exercise (Ex) training attenuates hypercholesterolemia-induced impairment of endothelium-dependent relaxation (EDR) in brachial (Br) arteries of adult male pigs by enhancing nitric oxide (NO)-mediated EDR. Adult male pigs were fed a normal-fat (NF) or high-fat/cholesterol (HF) diet for 20 wk. Four weeks after the diet was initiated, pigs were trained or remained sedentary (Sed) for 16 wk, yielding four groups: 1 ) NF-Sed, 2 ) NF-Ex, 3 ) HF-Sed, and 4 ) HF-Ex. EDR of Br artery rings was assessed in vitro with acetylcholine (ACh) and bradykinin (BK). ACh- and BK-induced relaxation was not impaired by HF; however, relaxation responses were enhanced by Ex in NF and HF arteries. To determine the mechanism(s) by which Ex improved EDR, ACh- and BK-induced relaxation was assessed in the presence of N G -nitro- L -arginine methyl ester ( L -NAME; to inhibit NO synthase), indomethacin (Indo; to inhibit cyclooxygenase), or L -NAME + Indo. ACh- and BK-induced relaxation was inhibited by L -NAME, and L -NAME + Indo, in all groups of arteries. Indo did not inhibit ACh-induced relaxation in any group but did inhibit BK-induced relaxation in HF-Ex arteries. In the presence of L -NAME or L -NAME + Indo, ACh- and BK-induced relaxation in HF-Ex arteries remained greater than in HF-Sed arteries. However, in the presence of Indo, ACh-induced relaxation in HF-Ex arteries was no longer greater than in HF-Sed arteries. These results indicate that EDR is not impaired by hypercholesterolemia in Br arteries from adult male pigs; however, Ex improves EDR in HF Br arteries by enhancing production of endothelium-derived hyperpolarizing factor and/or prostacyclin.
nitric oxide; prostacyclin; endothelium-derived hyperpolarizing factor; endothelial nitric oxide synthase; vascular smooth muscle
Address for reprint requests and other correspondence: C. R. Woodman, Dept. of Biomedical Sciences, W108 Veterinary Medicine, 1600 E. Rollins Rd., Univ. of Missouri, Columbia, MO 65211 (e-mail: woodmanc{at}missouri.edu ) |
---|---|
AbstractList | We tested the hypothesis that exercise (Ex) training attenuates hypercholesterolemia-induced impairment of endothelium-dependent relaxation (EDR) in brachial (Br) arteries of adult male pigs by enhancing nitric oxide (NO)-mediated EDR. Adult male pigs were fed a normal-fat (NF) or high-fat/cholesterol (HF) diet for 20 wk. Four weeks after the diet was initiated, pigs were trained or remained sedentary (Sed) for 16 wk, yielding four groups: 1) NF-Sed, 2) NF-Ex, 3) HF-Sed, and 4) HF-Ex. EDR of Br artery rings was assessed in vitro with acetylcholine (ACh) and bradykinin (BK). ACh- and BK-induced relaxation was not impaired by HF; however, relaxation responses were enhanced by Ex in NF and HF arteries. To determine the mechanism(s) by which Ex improved EDR, ACh- and BK-induced relaxation was assessed in the presence of N(G)-nitro-l-arginine methyl ester (l-NAME; to inhibit NO synthase), indomethacin (Indo; to inhibit cyclooxygenase), or l-NAME + Indo. ACh- and BK-induced relaxation was inhibited by l-NAME, and l-NAME + Indo, in all groups of arteries. Indo did not inhibit ACh-induced relaxation in any group but did inhibit BK-induced relaxation in HF-Ex arteries. In the presence of l-NAME or l-NAME + Indo, ACh- and BK-induced relaxation in HF-Ex arteries remained greater than in HF-Sed arteries. However, in the presence of Indo, ACh-induced relaxation in HF-Ex arteries was no longer greater than in HF-Sed arteries. These results indicate that EDR is not impaired by hypercholesterolemia in Br arteries from adult male pigs; however, Ex improves EDR in HF Br arteries by enhancing production of endothelium-derived hyperpolarizing factor and/or prostacyclin. We tested the hypothesis that exercise (Ex) training attenuates hypercholesterolemia-induced impairment of endothelium-dependent relaxation (EDR) in brachial (Br) arteries of adult male pigs by enhancing nitric oxide (NO)-mediated EDR. Adult male pigs were fed a normal-fat (NF) or high-fat/cholesterol (HF) diet for 20 wk. Four weeks after the diet was initiated, pigs were trained or remained sedentary (Sed) for 16 wk, yielding four groups: 1) NF-Sed, 2) NF-Ex, 3) HF-Sed, and 4) HF-Ex. EDR of Br artery rings was assessed in vitro with acetylcholine (ACh) and bradykinin (BK). ACh- and BK-induced relaxation was not impaired by HF; however, relaxation responses were enhanced by Ex in NF and HF arteries. To determine the mechanism(s) by which Ex improved EDR, ACh- and BK-induced relaxation was assessed in the presence of NG-nitro-L-arginine methyl ester (L-NAME; to inhibit NO synthase), indomethacin (Indo; to inhibit cyclooxygenase), or L-NAME + Indo. ACh- and BK-induced relaxation was inhibited by L-NAME, and L-NAME + Indo, in all groups of arteries. Indo did not inhibit ACh-induced relaxation in any group but did inhibit BK-induced relaxation in HF-Ex arteries. In the presence of L-NAME or L-NAME + Indo, ACh- and BK-induced relaxation in HF-Ex arteries remained greater than in HF-Sed arteries. However, in the presence of Indo, ACh-induced relaxation in HF-Ex arteries was no longer greater than in HF-Sed arteries. These results indicate that EDR is not impaired by hypercholesterolemia in Br arteries from adult male pigs; however, Ex improves EDR in HF Br arteries by enhancing production of endothelium-derived hyperpolarizing factor and/or prostacyclin. [PUBLICATION ABSTRACT] Department of Biomedical Sciences, University of Missouri, Columbia, Missouri Submitted 16 March 2005 ; accepted in final form 17 June 2005 We tested the hypothesis that exercise (Ex) training attenuates hypercholesterolemia-induced impairment of endothelium-dependent relaxation (EDR) in brachial (Br) arteries of adult male pigs by enhancing nitric oxide (NO)-mediated EDR. Adult male pigs were fed a normal-fat (NF) or high-fat/cholesterol (HF) diet for 20 wk. Four weeks after the diet was initiated, pigs were trained or remained sedentary (Sed) for 16 wk, yielding four groups: 1 ) NF-Sed, 2 ) NF-Ex, 3 ) HF-Sed, and 4 ) HF-Ex. EDR of Br artery rings was assessed in vitro with acetylcholine (ACh) and bradykinin (BK). ACh- and BK-induced relaxation was not impaired by HF; however, relaxation responses were enhanced by Ex in NF and HF arteries. To determine the mechanism(s) by which Ex improved EDR, ACh- and BK-induced relaxation was assessed in the presence of N G -nitro- L -arginine methyl ester ( L -NAME; to inhibit NO synthase), indomethacin (Indo; to inhibit cyclooxygenase), or L -NAME + Indo. ACh- and BK-induced relaxation was inhibited by L -NAME, and L -NAME + Indo, in all groups of arteries. Indo did not inhibit ACh-induced relaxation in any group but did inhibit BK-induced relaxation in HF-Ex arteries. In the presence of L -NAME or L -NAME + Indo, ACh- and BK-induced relaxation in HF-Ex arteries remained greater than in HF-Sed arteries. However, in the presence of Indo, ACh-induced relaxation in HF-Ex arteries was no longer greater than in HF-Sed arteries. These results indicate that EDR is not impaired by hypercholesterolemia in Br arteries from adult male pigs; however, Ex improves EDR in HF Br arteries by enhancing production of endothelium-derived hyperpolarizing factor and/or prostacyclin. nitric oxide; prostacyclin; endothelium-derived hyperpolarizing factor; endothelial nitric oxide synthase; vascular smooth muscle Address for reprint requests and other correspondence: C. R. Woodman, Dept. of Biomedical Sciences, W108 Veterinary Medicine, 1600 E. Rollins Rd., Univ. of Missouri, Columbia, MO 65211 (e-mail: woodmanc{at}missouri.edu ) We tested the hypothesis that exercise (Ex) training attenuates hypercholesterolemia-induced impairment of endothelium-dependent relaxation (EDR) in brachial (Br) arteries of adult male pigs by enhancing nitric oxide (NO)-mediated EDR. Adult male pigs were fed a normal-fat (NF) or high-fat/cholesterol (HF) diet for 20 wk. Four weeks after the diet was initiated, pigs were trained or remained sedentary (Sed) for 16 wk, yielding four groups: 1) NF-Sed, 2) NF-Ex, 3) HF-Sed, and 4) HF-Ex. EDR of Br artery rings was assessed in vitro with acetylcholine (ACh) and bradykinin (BK). ACh- and BK-induced relaxation was not impaired by HF; however, relaxation responses were enhanced by Ex in NF and HF arteries. To determine the mechanism(s) by which Ex improved EDR, ACh- and BK-induced relaxation was assessed in the presence of N G -nitro-l-arginine methyl ester (l-NAME; to inhibit NO synthase), indomethacin (Indo; to inhibit cyclooxygenase), or l-NAME + Indo. ACh- and BK-induced relaxation was inhibited by l-NAME, and l-NAME + Indo, in all groups of arteries. Indo did not inhibit ACh-induced relaxation in any group but did inhibit BK-induced relaxation in HF-Ex arteries. In the presence of l-NAME or l-NAME + Indo, ACh- and BK-induced relaxation in HF-Ex arteries remained greater than in HF-Sed arteries. However, in the presence of Indo, ACh-induced relaxation in HF-Ex arteries was no longer greater than in HF-Sed arteries. These results indicate that EDR is not impaired by hypercholesterolemia in Br arteries from adult male pigs; however, Ex improves EDR in HF Br arteries by enhancing production of endothelium-derived hyperpolarizing factor and/or prostacyclin. We tested the hypothesis that exercise (Ex) training attenuates hypercholesterolemia-induced impairment of endothelium-dependent relaxation (EDR) in brachial (Br) arteries of adult male pigs by enhancing nitric oxide (NO)-mediated EDR. Adult male pigs were fed a normal-fat (NF) or high-fat/cholesterol (HF) diet for 20 wk. Four weeks after the diet was initiated, pigs were trained or remained sedentary (Sed) for 16 wk, yielding four groups: 1) NF-Sed, 2) NF-Ex, 3) HF-Sed, and 4) HF-Ex. EDR of Br artery rings was assessed in vitro with acetylcholine (ACh) and bradykinin (BK). ACh- and BK-induced relaxation was not impaired by HF; however, relaxation responses were enhanced by Ex in NF and HF arteries. To determine the mechanism(s) by which Ex improved EDR, ACh- and BK-induced relaxation was assessed in the presence of N super(G)-nitro-L-arginine methyl ester (L-NAME; to inhibit NO synthase), indomethacin (Indo; to inhibit cyclooxygenase), or L-NAME + Indo. ACh- and BK-induced relaxation was inhibited by L-NAME, and L-NAME + Indo, in all groups of arteries. Indo did not inhibit ACh-induced relaxation in any group but did inhibit BK-induced relaxation in HF-Ex arteries. In the presence of L-NAME or L-NAME + Indo, ACh- and BK-induced relaxation in HF-Ex arteries remained greater than in HF-Sed arteries. However, in the presence of Indo, ACh-induced relaxation in HF-Ex arteries was no longer greater than in HF-Sed arteries. These results indicate that EDR is not impaired by hypercholesterolemia in Br arteries from adult male pigs; however, Ex improves EDR in HF Br arteries by enhancing production of endothelium-derived hyperpolarizing factor and/or prostacyclin. |
Author | Thompson, Mark A Woodman, Christopher R Turk, James R Laughlin, M. Harold |
Author_xml | – sequence: 1 fullname: Woodman, Christopher R – sequence: 2 fullname: Thompson, Mark A – sequence: 3 fullname: Turk, James R – sequence: 4 fullname: Laughlin, M. Harold |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17568192$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15976363$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkU9v1DAQxS1URLeFrwAWEhWXXfwndpIjqlpAqsSlnC3HmWy8cuxgJ2X3wmevl40oQkJcPLL9e29m9C7QmQ8eEHpDyYZSwT7s9Di6sT8kG9yGEFbzDSNEPEOr_MvWVBJ6hlZVKci6FFV5ji5S2hFCi0LQF-icirqUXPIV-nnj2zlqbwDDHqKxCfAUtfXWb7EdxhgeIGHwbZh6cHYe1i2M-Qp-whGc3uvJBo-tx03UprfaYR0niDaruhgG3B_GbNsHByk_5zJYgwftAI92m16i5512CV4t9RJ9u725v_68vvv66cv1x7u1EQWf8klAs1Yy2RFeSA4dMdAY1hgiuNbQNTXoqmEVp1K3NakY5y2rZak74LLQ_BJdnXzzQt_nPIoabDLgnPYQ5qRkJSoqS_FfkJZSyrqoMvj2L3AX5ujzEooxRitGijpD5QkyMaQUoVNjtIOOB0WJOgap_gxS_QpSHYPMyteL_dwM0D7pluQy8G4BdDLadccMbXriSiErWrPMFSeut9v-h42glm5he1C3s3P3sJ-OY9S1KhQtKFNj22XZ-3_LMq1-4_wRP1jRRg |
CODEN | JAPHEV |
CitedBy_id | crossref_primary_10_1111_j_1743_6109_2007_00731_x crossref_primary_10_1258_ebm_2010_010148 crossref_primary_10_1016_j_cbpa_2006_10_018 crossref_primary_10_1007_s11010_022_04610_1 crossref_primary_10_1016_S1734_1140_10_70305_4 crossref_primary_10_1590_S1677_54492010000200007 crossref_primary_10_1590_s1980_657420220005522 crossref_primary_10_1016_j_cbpa_2006_08_037 crossref_primary_10_6061_clinics_2012_08_12 crossref_primary_10_14814_phy2_13502 crossref_primary_10_1016_j_exger_2013_08_001 crossref_primary_10_1111_micc_12674 crossref_primary_10_4199_C00032ED1V01Y201105ISP020 crossref_primary_10_3389_fcvm_2024_1388528 crossref_primary_10_4199_C00031ED1V01Y201105ISP019 crossref_primary_10_1161_HYPERTENSIONAHA_116_07954 crossref_primary_10_1016_j_msard_2022_103557 crossref_primary_10_1186_1472_6793_8_12 crossref_primary_10_1113_expphysiol_2013_075838 crossref_primary_10_1097_FJC_0000000000000346 crossref_primary_10_1254_jphs_13016FP crossref_primary_10_1016_j_cbpa_2007_04_020 crossref_primary_10_1080_10623320802092211 crossref_primary_10_1152_ajpheart_00294_2010 crossref_primary_10_1152_ajpheart_01026_2005 |
Cites_doi | 10.1016/0002-8703(94)90251-8 10.1016/0741-5214(89)90448-5 10.1152/jappl.2001.90.2.501 10.1152/japplphysiol.01025.2002 10.1161/01.CIR.88.6.2541 10.1053/meta.2002.36313 10.1152/ajpregu.1999.276.4.R1023 10.1152/jappl.1997.82.5.1438 10.1161/01.ATV.21.1.122 10.1161/01.ATV.19.12.2981 10.1161/01.RES.74.2.349 10.1006/mvre.1998.2083 10.1161/01.CIR.89.5.2308 10.1152/japplphysiol.00768.2003 10.1161/01.RES.70.3.465 10.1152/jappl.2001.90.1.216 10.3109/07853899509002587 10.1249/00005768-199508000-00006 10.1152/ajpheart.1997.273.6.H2575 10.1161/01.RES.64.5.900 10.1161/01.RES.73.5.829 10.1249/00005768-199410000-00012 10.1161/01.ATV.19.11.2769 10.1161/01.RES.63.5.903 10.1152/japplphysiol.00767.2003 10.1016/0735-1097(89)90318-5 10.1161/01.CIR.0000028581.07992.56 10.1152/jappl.1994.76.5.2241 |
ContentType | Journal Article |
Copyright | 2006 INIST-CNRS Copyright American Physiological Society Oct 2005 |
Copyright_xml | – notice: 2006 INIST-CNRS – notice: Copyright American Physiological Society Oct 2005 |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7QR 7TK 7TS 7U7 8FD C1K FR3 P64 7X8 |
DOI | 10.1152/japplphysiol.00293.2005 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Neurosciences Abstracts Physical Education Index Toxicology Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Technology Research Database Toxicology Abstracts Chemoreception Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Physical Education Index Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitleList | MEDLINE Technology Research Database MEDLINE - Academic CrossRef Physical Education Index |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology |
EISSN | 1522-1601 |
EndPage | 1421 |
ExternalDocumentID | 913351031 10_1152_japplphysiol_00293_2005 15976363 17568192 jap_99_4_1412 |
Genre | Research Support, U.S. Gov't, P.H.S Journal Article Research Support, N.I.H., Extramural Feature |
GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: HL-52490 – fundername: NIA NIH HHS grantid: AG-00988 – fundername: NHLBI NIH HHS grantid: HL-36088 |
GroupedDBID | - 02 2WC 39C 3O- 4.4 53G 55 5VS 85S AALRV ABFLS ABOCM ABUFD ACGFS ACIWK ACPRK ADBBV ADBIT AEILP AENEX AEULQ AFDAS AFRAH AGCDD ALMA_UNASSIGNED_HOLDINGS BAWUL C1A CS3 DIK DU5 E3Z EBS EJD F5P FRP GJ GX1 H13 H~9 KQ8 L7B MYA NEJ O0- OHT OK1 P-O P2P PQEST PQQKQ RAP RHF RHI RPL SJN UHB UKR UPT WH7 WOQ X X7M YCJ --- -~X .55 .GJ 08R 18M 1CY 29J 476 8M5 AAFWJ AAUGY ABCQX ABDNZ ABKWE ACBEA ACGFO ACKIV ACYGS ADFNX AETEA AFMIJ AFOSN AGNAY AI. AIDAL AJUXI BKKCC BTFSW C2- EMOBN F3I IQODW ITBOX J5H MVM P6G RPRKH TR2 VH1 W8F XOL XSW YBH YQJ YQT YWH ZXP ~02 CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7QR 7TK 7TS 7U7 8FD C1K FR3 P64 7X8 |
ID | FETCH-LOGICAL-c543t-c50ea2d626f03463ef0cebc2bc053aaefb9ea8b28316ad908233d2967afe364a3 |
ISSN | 8750-7587 |
IngestDate | Fri Oct 25 00:39:15 EDT 2024 Sun Sep 29 07:21:35 EDT 2024 Thu Oct 10 18:59:21 EDT 2024 Thu Nov 21 21:20:15 EST 2024 Sat Sep 28 07:43:26 EDT 2024 Sun Oct 29 17:06:01 EDT 2023 Mon May 06 11:51:25 EDT 2019 Tue Jan 05 17:53:32 EST 2021 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | Physical exercise endothelium-derived hyperpolarizing factor: endothelial nitric oxide synthase Physical training Prostaglandin I2 Lipids Smooth muscle Male Hyperlipoproteinemia Lipoprotein Relaxation Endurance Dyslipemia Ungulata vascular smooth muscle Enzyme prostacyclin Brachial artery Metabolic diseases Cholesterol Nitric-oxide synthase Endothelium Pig Vertebrata Mammalia Hypercholesterolemia Nitric oxide Artiodactyla Oxidoreductases |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c543t-c50ea2d626f03463ef0cebc2bc053aaefb9ea8b28316ad908233d2967afe364a3 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
PMID | 15976363 |
PQID | 222182049 |
PQPubID | 40905 |
PageCount | 10 |
ParticipantIDs | pubmed_primary_15976363 crossref_primary_10_1152_japplphysiol_00293_2005 pascalfrancis_primary_17568192 proquest_miscellaneous_17666948 highwire_physiology_jap_99_4_1412 proquest_miscellaneous_68581675 proquest_journals_222182049 |
PublicationCentury | 2000 |
PublicationDate | 2005-10-01 |
PublicationDateYYYYMMDD | 2005-10-01 |
PublicationDate_xml | – month: 10 year: 2005 text: 2005-10-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | Bethesda, MD |
PublicationPlace_xml | – name: Bethesda, MD – name: United States – name: Bethesda |
PublicationTitle | Journal of applied physiology (1985) |
PublicationTitleAlternate | J Appl Physiol (1985) |
PublicationYear | 2005 |
Publisher | Am Physiological Soc American Physiological Society |
Publisher_xml | – name: Am Physiological Soc – name: American Physiological Society |
References | R21 R20 R23 R22 R25 R24 R27 R26 R28 R1 R2 R3 R4 R5 R6 R7 R8 R9 R10 R12 R11 R14 R13 R16 R15 R18 R17 R19 |
References_xml | – ident: R5 doi: 10.1016/0002-8703(94)90251-8 – ident: R6 doi: 10.1016/0741-5214(89)90448-5 – ident: R10 doi: 10.1152/jappl.2001.90.2.501 – ident: R28 doi: 10.1152/japplphysiol.01025.2002 – ident: R2 doi: 10.1161/01.CIR.88.6.2541 – ident: R21 doi: 10.1053/meta.2002.36313 – ident: R8 doi: 10.1152/ajpregu.1999.276.4.R1023 – ident: R12 doi: 10.1152/jappl.1997.82.5.1438 – ident: R25 doi: 10.1161/01.ATV.21.1.122 – ident: R4 doi: 10.1161/01.ATV.19.12.2981 – ident: R16 doi: 10.1161/01.RES.74.2.349 – ident: R20 doi: 10.1006/mvre.1998.2083 – ident: R13 doi: 10.1161/01.CIR.89.5.2308 – ident: R22 doi: 10.1152/japplphysiol.00768.2003 – ident: R7 doi: 10.1161/01.RES.70.3.465 – ident: R11 doi: 10.1152/jappl.2001.90.1.216 – ident: R14 doi: 10.3109/07853899509002587 – ident: R9 doi: 10.1249/00005768-199508000-00006 – ident: R26 doi: 10.1152/ajpheart.1997.273.6.H2575 – ident: R17 doi: 10.1161/01.RES.64.5.900 – ident: R24 doi: 10.1161/01.RES.73.5.829 – ident: R15 doi: 10.1249/00005768-199410000-00012 – ident: R1 doi: 10.1161/01.ATV.19.11.2769 – ident: R3 doi: 10.1161/01.RES.63.5.903 – ident: R27 doi: 10.1152/japplphysiol.00767.2003 – ident: R18 doi: 10.1016/0735-1097(89)90318-5 – ident: R23 doi: 10.1161/01.CIR.0000028581.07992.56 – ident: R19 doi: 10.1152/jappl.1994.76.5.2241 |
SSID | ssj0014451 |
Score | 1.9930981 |
Snippet | Department of Biomedical Sciences, University of Missouri, Columbia, Missouri
Submitted 16 March 2005
; accepted in final form 17 June 2005
We tested the... We tested the hypothesis that exercise (Ex) training attenuates hypercholesterolemia-induced impairment of endothelium-dependent relaxation (EDR) in brachial... |
SourceID | proquest crossref pubmed pascalfrancis highwire |
SourceType | Aggregation Database Index Database Enrichment Source Publisher |
StartPage | 1412 |
SubjectTerms | Acetylcholine - pharmacology Animals Biological and medical sciences Blood vessels Brachial Artery - drug effects Brachial Artery - metabolism Brachial Artery - physiopathology Bradykinin - pharmacology Caveolin 1 - metabolism Endothelium, Vascular - physiopathology Exercise Fundamental and applied biological sciences. Psychology Hogs Hypercholesterolemia - physiopathology Immunoblotting Immunohistochemistry In Vitro Techniques Male Nitric oxide Nitric Oxide Synthase Type III - metabolism Nitroprusside - pharmacology Physical Conditioning, Animal Physical Endurance Superoxide Dismutase - metabolism Superoxide Dismutase-1 Swine Swine, Miniature Vasodilation Vasodilator Agents - pharmacology |
Title | Endurance exercise training improves endothelium-dependent relaxation in brachial arteries from hypercholesterolemic male pigs |
URI | http://jap.physiology.org/cgi/content/abstract/99/4/1412 https://www.ncbi.nlm.nih.gov/pubmed/15976363 https://www.proquest.com/docview/222182049 https://search.proquest.com/docview/17666948 https://search.proquest.com/docview/68581675 |
Volume | 99 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF5FRUJcELQ8QqEsEuJSGeLs-rHHCqWqoC1CSkVuq7W9biu1dpTYEuXAv-V_MLMPO1FTBFycyF4_5_PMzvibGULegsUqwYwngUpCFfAk5oEKQxHkWcFSmJEWnGFy8slpfHTGP82i2WDwa4W11DbZ-_zHxryS_5EqrAO5YpbsP0i2OyisgP8gX1iChGH5VzKeVEW7MJx_3zmpa_mA6Y-LGkvK6qrALKury_Y68C1vG5PD8l15piO4zMh5vto3DE9wnm3ayQU4qQvUj6acAvwgkf4aTMr-_NLF12_Pa5Wb15qYia3whMWgRBqtRB2-1XXhYq8r5Q169mLPU7HpRH3Iddpacreh9_Y7HKv2_MI1nz_B1KTaFoLtIhpRx41rVpII0AT46zRwdSzWXj-CpzUKwN2x9lo7_Q2-dRi7ozkFbzswOSDzFW0dckvhvm1GorFpXwAPzD0sDLwJZmJwveX0bIHTL_Lw7PhYTiez6fpWM1EQIWNYuBCc9HtYrxFbPHz-2n_swhpxNgxt78fREOEiPtxxCeuTKF_YGnm9agnPqrQ9We52mszkafqIPHTooAcWwo_JQFfbZOegUk19fUPf0U4GN9vk_omje-yQnx3AqQc49QCnHuB0I8BpD3B6WVEPcOoBThHgdBPAKQKcIsCfkLPDyfTjUeAahgR5xFkDy5FW4wJ89HLEeMx0Ocp1lo-zHEyNUrrMhFZpBvopjFUh8CMzK8YiTlSpWcwVe0q2qrrSzwlNUq5UJvIoTGPQYHkKE3ut45zrKBPFKB-SkZeAnNu6MNL409FYrgpNGqFhs9doSAIvKdm_ghJDTVMADO4mhOQSUSnnRTkkbzaNh2GyGzcke2si768lwcqCAgbsegxIp7mWEnwC7NvAxZC87raCWcFvharSdbuUWDc2Fjy9ewQ2rgjjBG7rmYVWf-4IfBwWsxd_PPcuedC__C_JVrNo9SuY4DfZnnk9fgP-YQjH |
link.rule.ids | 314,780,784,27924,27925 |
linkProvider | Colorado Alliance of Research Libraries |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Endurance+exercise+training+improves+endothelium-dependent+relaxation+in+brachial+arteries+from+hypercholesterolemic+male+pigs&rft.jtitle=Journal+of+applied+physiology+%281985%29&rft.au=Woodman%2C+Christopher+R&rft.au=Thompson%2C+Mark+A&rft.au=Turk%2C+James+R&rft.au=Laughlin%2C+M+Harold&rft.date=2005-10-01&rft.pub=American+Physiological+Society&rft.issn=8750-7587&rft.eissn=1522-1601&rft.volume=99&rft.issue=4&rft.spage=1412&rft_id=info:doi/10.1152%2Fjapplphysiol.00293.2005&rft.externalDBID=NO_FULL_TEXT&rft.externalDocID=913351031 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=8750-7587&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=8750-7587&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=8750-7587&client=summon |