Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 120; no. 22; p. e2300155120
• Main Authors: Hosoya, Tadashi, Oba, Seiya, Komiya, Yoji, Kawata, Daisuke, Kamiya, Mari, Iwai, Hideyuki, Miyamoto, Sho, Kataoka, Michiyo, Tobiume, Minoru, Kanno, Takayuki, Ainai, Akira, Sato, Hiroyuki, Hirakawa, Akihiro, Mitsui, Yuichi, Satoh, Takashi, Wakabayashi, Kenji, Yamada, Tetsuya, Otomo, Yasuhiro, Miyazaki, Yasunari, Hasegawa, Hideki, Suzuki, Tadaki, Yasuda, Shinsuke
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 30.05.2023
• Subjects: Adipose tissue; Animal models; Animals; Antibodies; Biological Sciences; Coronaviruses; COVID-19; COVID-19 - complications; Cytokine storm; Cytokines; Genomes; Health services; Immune response; Inflammation; Interleukin 6; Interleukin 6 receptors; Leptin; Leptin - genetics; Macrophages; Malus; Mice; Mice, Inbred C57BL; Mice, Obese; Mortality; Obesity; Obesity - complications; Obesity - genetics; Patients; Proteins; Receptors; Replenishment; Retrospective Studies; Risk factors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Viral diseases; COVID-19; cytokine storm; risk factor; obesity; abdominal adiposity

Obesity has been recognized as one of the most significant risk factors for the deterioration and mortality associated with COVID-19, but the significance of obesity itself differs among ethnicity. Multifactored analysis of our single institute–based retrospective cohort revealed that high visceral...