Plasma exosomal miR-122 regulates the efficacy of metformin via AMPK in type 2 diabetes and hepatocellular carcinoma

• Published in: Heliyon Vol. 8; no. 11; p. e11503
• Main Authors: Peng, Hui, Hou, Mei, Wu, Zixin, Wang, Jing, Zhou, Man, Zhuang, Xiangjin, Xing, Jiayu, Tao, Qianqian, Huang, Long, Zhou, Fuhai, Zhang, Shengming, Feng, Qiyu, Hou, Yilin, Yu, Qinsheng
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2022; Elsevier
• Subjects: AMPK; Exosome; exosomes; glucose; glycemic control; Hepatocellular carcinoma; hepatocytes; hepatoma; homeostasis; Metformin; miR-122; noninsulin-dependent diabetes mellitus; phosphorylation; therapeutics; Type 2 diabetes; Type 2 diabetes; Hepatocellular carcinoma; AMPK; Metformin; Exosome; miR-122

Metformin is a drug that has been applied in clinical use for many years for the treatment of type 2 diabetes mellitus (T2DM). It achieves its function through multiple targets and modulation of multiple signaling pathways. To date, the mechanism of the action of metformin is still not fully underst...