EBV BMRF-2 facilitates cell-to-cell spread of virus within polarized oral epithelial cells

• Published in: Virology (New York, N.Y.) Vol. 388; no. 2; pp. 335 - 343
• Main Authors: Xiao, Jianqiao, Palefsky, Joel M, Herrera, Rossana, Berline, Jennifer, Tugizov, Sharof M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.06.2009
• Subjects: Cell Line, Tumor; EBV BMRF-2; EBV cell-to-cell spread; Epithelial Cells - cytology; Epithelial Cells - metabolism; Epithelial Cells - virology; Epstein-Barr virus; Herpesvirus 4, Human - chemistry; Herpesvirus 4, Human - genetics; Herpesvirus 4, Human - physiology; Humans; Infectious Disease; Lymphocytes - metabolism; Lymphocytes - virology; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mouth - cytology; Mouth - virology; Protein Sorting Signals; Protein Transport; Viral Proteins - genetics; Viral Proteins - metabolism; EBV BMRF-2; EBV cell-to-cell spread

Abstract We previously reported that the Epstein–Barr virus (EBV) BMRF-2 protein plays an important role in EBV infection of polarized oral epithelial cells by interacting with β1 and αv family integrins. Here we show that infection of polarized oral epithelial cells with B27-BMRF-2low recombinant v...