Diversity of escape variant mutations in Simian virus 40 large tumor antigen (SV40 Tag) epitopes selected by cytotoxic T lymphocyte (CTL) clones

• Published in: Virology (New York, N.Y.) Vol. 364; no. 1; pp. 155 - 168
• Main Authors: Mylin, Lawrence M, Schell, Todd D, Epler, Melanie, Kusuma, Caroline, Assis, David, Matsko, Chelsea, Smith, Alexandra, Allebach, April, Tevethia, Satvir S
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.07.2007
• Subjects: Amino Acid Sequence; Animals; Antigens, Polyomavirus Transforming - genetics; Antigens, Polyomavirus Transforming - immunology; Base Sequence; CD8+ T lymphocyte; Cell Line, Transformed; CTL clone; CTL epitope; CTL escape variant; Cytotoxicity; DNA, Viral - genetics; Epitope mutation; Epitopes - genetics; Genetic Variation; Immunity, Cellular; In Vitro Techniques; Infectious Disease; Mice; Mutation; Simian virus 40; Simian virus 40 - genetics; Simian virus 40 - immunology; SV40 Tag; T-Lymphocytes, Cytotoxic - immunology; SV40 Tag; CD8+ T lymphocyte; Epitope mutation; CTL epitope; Cytotoxicity; CTL escape variant; CTL clone

Abstract To better understand the relationship between epitope variation and tumor escape from immune surveillance, SV40 T antigen-transformed B6/K-0 cells were subjected to selection with individual CTL clones specific for the SV40 T antigen H-2Db -restricted epitopes I or V. CTL-resistant populati...