Intravenous plus oral amiodarone, atrial septal pacing, or both strategies to prevent post-cardiothoracic surgery atrial fibrillation: The atrial fibrillation suppression trial II (AFIST II)

• Published in: Circulation (New York, N.Y.) Vol. 108; no. 10; pp. 200 - 206
• Main Authors: WHITE, C. Michael, CARON, Michael F, KALUS, James S, ROSE, Heidi, SONG, Jessica, REDDY, Prabashni, GALLAGHER, Robert, KLUGER, Jeffrey
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 09.09.2003; American Heart Association, Inc
• Subjects: Administration, Oral; Aged; Amiodarone - administration & dosage; Amiodarone - therapeutic use; Atrial Fibrillation - economics; Atrial Fibrillation - prevention & control; Biological and medical sciences; Cardiac Pacing, Artificial; Combined Modality Therapy; Coronary Artery Bypass; Endpoint Determination; Female; Heart Atria; Heart Septum; Heart Valve Prosthesis Implantation; Hospital Costs; Humans; Infusions, Intravenous; Length of Stay; Male; Medical sciences; Middle Aged; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Thoracic Surgical Procedures; Antianginal agent; Heart; Intravenous administration; pacemaker; Arrhythmia; Coronary vasodilator agent; Cardiovascular disease; Atrial septum; Amiodarone; Iodine Organic compounds; Prevention; Heart disease; Surgery; Phase II trial; Human; Treatment efficiency; Atrial fibrillation; Oral administration; Instrumentation therapy; Thorax; Antiarrhythmic agent; Excitability disorder; Instrumental stimulation; Chemotherapy; artificial; Treatment; Comparative study

The effect of a hybrid intravenous and oral prophylactic amiodarone regimen on postcardiothoracic surgery (CTS) atrial fibrillation (AF) is unknown. The impact of active atrial septal pacing on post-CTS AF has not been well characterized. In addition, the effect of using both amiodarone and atrial s...