Design, synthesis and biological evaluation of new 3,4-dihydroquinoxalin-2(1H)-one derivatives as soluble guanylyl cyclase (sGC) activators - Kintos, Dionysios-Panagiotis; Salagiannis, Konstantinos; Vazoura, Vasiliki; Wittrien, Theresa; Papakyriakou, Athanasios; Nikolaropoulos, Sotiris S.; Behrends, Soenke; Topouzis, Stavros; Fousteris, Manolis A. (Heliyon, 2022)
Keywords: 3,4-Dihydroquinoxalin-2(1H)-one; biological assessment; domain; enzyme activity; guanylate cyclase; heme; humans; mutants; Nitric oxide; nitroprusside; oxidants; prostatic neoplasms; sGC activators; smooth muscle; Soluble guanylyl cyclase; synergism; sGC activators; Nitric oxide; Soluble guanylyl cyclase; 3,4-Dihydroquinoxalin-2(1H)-one