Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain

Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). We report 2...

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Published in	Emerging infectious diseases Vol. 24; no. 4; pp. 735 - 740
Main Authors	Lahra, Monica M., Martin, Irene, Demczuk, Walter, Jennison, Amy V., Lee, Ken-Ichi, Nakayama, Shu-Ichi, Lefebvre, Brigitte, Longtin, Jean, Ward, Alison, Mulvey, Michael R., Wi, Teodora, Ohnishi, Makoto, Whiley, David
Format	Journal Article
Language	English
Published	United States U.S. National Center for Infectious Diseases 01.04.2018 Centers for Disease Control and Prevention
Subjects	beta-Lactam Resistance beta-Lactamase Inhibitors - pharmacology Care and treatment cefixime Ceftriaxone Ceftriaxone - pharmacology Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Genome, Bacterial Genomics - methods gonorrhea Gonorrhea - microbiology gonorrhoeae Humans Microbial drug resistance Microbial Sensitivity Tests Neisseria gonorrhoeae - classification Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics Neisseria N. gonorrhoeae Phylogeny Polymorphism, Single Nucleotide Strain Tetracyclines β-lactam gentamycin penicillin gonorrhea Japan spectinomycin azithromycin β-lactam cephalosporin Spain Canada ceftriaxone Neisseria gonorrhoeae antimicrobial resistance China cefixime tetracycline Australia France penA gene ciprofloxacin penicillinase
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Abstract	Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). We report 2 instances of the FC428 clone in Australia in heterosexual men traveling from Asia. Our bioinformatic analyses included core single-nucleotide variation phylogeny and in silico molecular typing; phylogenetic analysis showed close genetic relatedness among all 5 isolates. Results showed multilocus sequence type 1903; N. gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) 233; and harboring of mosaic penA allele encoding alterations A311V and T483S (penA-60.001), associated with ceftriaxone resistance. Our results provide further evidence of international transmission of ceftriaxone-resistant N. gonorrhoeae. We recommend increasing awareness of international spread of this drug-resistant strain, strengthening surveillance to include identifying treatment failures and contacts, and strengthening international sharing of data.
AbstractList	Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). We report 2 instances of the FC428 clone in Australia in heterosexual men traveling from Asia. Our bioinformatic analyses included core single-nucleotide variation phylogeny and in silico molecular typing; phylogenetic analysis showed close genetic relatedness among all 5 isolates. Results showed multilocus sequence type 1903; N. gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) 233; and harboring of mosaic penA allele encoding alterations A311V and T483S (penA-60.001), associated with ceftriaxone resistance. Our results provide further evidence of international transmission of ceftriaxone-resistant N. gonorrhoeae. We recommend increasing awareness of international spread of this drug-resistant strain, strengthening surveillance to include identifying treatment failures and contacts, and strengthening international sharing of data. Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). We report 2 instances of the FC428 clone in Australia in heterosexual men traveling from Asia. Our bioinformatic analyses included core single-nucleotide variation phylogeny and in silico molecular typing; phylogenetic analysis showed close genetic relatedness among all 5 isolates. Results showed multilocus sequence type 1903; N. gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) 233; and harboring of mosaic penA allele encoding alterations A311V and T483S ( penA -60.001), associated with ceftriaxone resistance. Our results provide further evidence of international transmission of ceftriaxone-resistant N. gonorrhoeae . We recommend increasing awareness of international spread of this drug-resistant strain, strengthening surveillance to include identifying treatment failures and contacts, and strengthening international sharing of data. Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). We report 2 instances of the FC428 clone in Australia in heterosexual men traveling from Asia. Our bioinformatic analyses included core single-nucleotide variation phylogeny and in silico molecular typing; phylogenetic analysis showed close genetic relatedness among all 5 isolates. Results showed multilocus sequence type 1903; N. gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) 233; and harboring of mosaic penA allele encoding alterations A311V and T483S (penA-60.001), associated with ceftriaxone resistance. Our results provide further evidence of international transmission of ceftriaxone-resistant N. gonorrhoeae. We recommend increasing awareness of international spread of this drug-resistant strain, strengthening surveillance to include identifying treatment failures and contacts, and strengthening international sharing of data.Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). We report 2 instances of the FC428 clone in Australia in heterosexual men traveling from Asia. Our bioinformatic analyses included core single-nucleotide variation phylogeny and in silico molecular typing; phylogenetic analysis showed close genetic relatedness among all 5 isolates. Results showed multilocus sequence type 1903; N. gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) 233; and harboring of mosaic penA allele encoding alterations A311V and T483S (penA-60.001), associated with ceftriaxone resistance. Our results provide further evidence of international transmission of ceftriaxone-resistant N. gonorrhoeae. We recommend increasing awareness of international spread of this drug-resistant strain, strengthening surveillance to include identifying treatment failures and contacts, and strengthening international sharing of data.
Audience	Professional Academic
Author	Ohnishi, Makoto Wi, Teodora Demczuk, Walter Ward, Alison Mulvey, Michael R. Jennison, Amy V. Nakayama, Shu-Ichi Lefebvre, Brigitte Lahra, Monica M. Martin, Irene Lee, Ken-Ichi Whiley, David Longtin, Jean
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29553335$$D View this record in MEDLINE/PubMed
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Snippet	Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a... Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a...
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SubjectTerms	beta-Lactam Resistance beta-Lactamase Inhibitors - pharmacology Care and treatment cefixime Ceftriaxone Ceftriaxone - pharmacology Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Genome, Bacterial Genomics - methods gonorrhea Gonorrhea - microbiology gonorrhoeae Humans Microbial drug resistance Microbial Sensitivity Tests Neisseria gonorrhoeae - classification Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics Neisseria N. gonorrhoeae Phylogeny Polymorphism, Single Nucleotide Strain Tetracyclines β-lactam
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Title	Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain
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