Metabolic Fate of Dietary Carnitine in Human Adults: Identification and Quantification of Urinary and Fecal Metabolites

• Published in: The Journal of nutrition Vol. 121; no. 4; pp. 539 - 546
• Main Authors: Rebouche, Charles J., Chenard, Catherine A.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.04.1991; American Society for Nutritional Sciences
• Subjects: absorption; administration & dosage; Adult; adulte; adultos; adults; aminas; amine; AMINES; AMINO ACIDS; AMMONIUM COMPOUNDS; analogs & derivatives; analysis; ANIMALS; balance studies; BASIC BIOLOGICAL SCIENCES; BETAINE; Betaine - analogs & derivatives; Betaine - analysis; bioavailability; Biological and medical sciences; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; Biotransformation; CARBOXYLIC ACIDS; carnitina; CARNITINE; Carnitine - administration & dosage; Carnitine - pharmacokinetics; Carnitine - urine; chemistry; Chromatography, Ion Exchange; COUNTING TECHNIQUES; diagnostic use; DIET; dieta; disponibilidad de nutrientes; DRUGS; element nutritif disponible; Enzymes. Coenzymes. Vitamins. Pigments; excrecion; excretion; experimental diets; experimentation; experimentos; experiments; faeces; FECES; Feces - chemistry; Fundamental and applied biological sciences. Psychology; heces; hombres; homme; Humans; HYDROGEN COMPOUNDS; HYDROXY ACIDS; ISOTOPE APPLICATIONS; isotope labeling; L-carnitine; LIPOTROPIC FACTORS; Male; MAMMALS; MAN; MATERIALS; men; METABOLISM; metabolisme; metabolismo; Metabolisms and neurohumoral controls; metabolite; METABOLITES; metabolitos; Methylamines; Methylamines - analysis; nutrient availability; ORAL ADMINISTRATION; ORGANIC ACIDS; ORGANIC COMPOUNDS; orina; pharmacokinetics; PRIMATES; QUATERNARY COMPOUNDS; regime alimentaire; SCINTILLATION COUNTING; technique des traceurs; tecnicas de trazadores; TRACER TECHNIQUES; trimethylamine; trimethylamine N-oxide; Tritium; TRITIUM COMPOUNDS; urine; VERTEBRATES; Vertebrates: anatomy and physiology, studies on body, several organs or systems; VITAMIN B GROUP; VITAMINS; WASTES 550501 > Metabolism > Tracer Techniques; γ-butyrobetaine; L-carnitine; trimethylamine N-oxide; absorption; humans; γ-butyrobetaine; Human; Excretion; Absorption; Diet; Metabolite; Vitamin; Metabolism; Feeding; Carnitine

Results of kinetic and pharmacokinetic studies have suggested that dietary carnitine is not totally absorbed and is in part degraded in the gastrointestinal tract of humans. To determine the metabolic fate of dietary carnitine in humans, we administered orally a tracer dose of [methyl-3H]L-carnitine...