Total ApoE and ApoE4 Isoform Assays in an Alzheimer's Disease Case-control Study by Targeted Mass Spectrometry (n = 669): A Pilot Assay for Methionine-containing Proteotypic Peptides - Simon, Romain; Girod, Marion; Fonbonne, Catherine; Salvador, Arnaud; Clément, Yohann; Lantéri, Pierre; Amouyel, Philippe; Lambert, Jean Charles; Lemoine, Jérôme (Molecular & cellular proteomics, 2012)
Keywords: Alzheimer Disease - blood; Alzheimer Disease - metabolism; Amino Acid Sequence; Analytical chemistry; Apolipoprotein E4 - blood; Apolipoprotein E4 - chemistry; Apolipoprotein E4 - metabolism; Biochemistry; Biochemistry, Molecular Biology; Calibration; Case-Control Studies; Chemical Sciences; Cohort Studies; Humans; Hydrolysis; Life Sciences; Mass Spectrometry - methods; Methionine - metabolism; Molecular Sequence Data; Oxidation-Reduction; Peptides - blood; Peptides - chemistry; Peptides - metabolism; Pilot Projects; Principal Component Analysis; Protein Isoforms - chemistry; Protein Isoforms - metabolism; Reproducibility of Results; Time Factors; E GENE; MULTIPLEXED ASSAYS; LINKAGE DISEQUILIBRIUM; QUANTITATIVE PROTEOMICS; BIOMARKER DISCOVERY; REGULATORY REGION; APOLIPOPROTEIN-E APOE; PROMOTER POLYMORPHISM; ABUNDANCE PROTEINS; CEREBROSPINAL-FLUID