Protostemonine effectively attenuates lipopolysaccharide-induced acute lung injury in mice - Wu, Ya-xian; He, Hui-qiong; Nie, Yun-juan; Ding, Yun-he; Sun, Lei; Qian, Feng (Acta pharmacologica Sinica, 2018)
Keywords: Acute Lung Injury - chemically induced; Acute Lung Injury - prevention & control; AKT protein; Alkaloids - administration & dosage; Alkaloids - therapeutic use; Animals; Biomedical and Life Sciences; Biomedicine; Bone marrow; Cell activation; Edema; Immunology; Inflammation; Interleukin 6; Interleukin-1beta - metabolism; Interleukin-6 - metabolism; Internal Medicine; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Lung - pathology; Lungs; Macrophage Activation; Macrophages; Macrophages - metabolism; MAP kinase; Medical Microbiology; Mice; Mice, Inbred C57BL; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; Nitric-oxide synthase; Original; original-article; p38 Mitogen-Activated Protein Kinases - metabolism; Peroxidase - metabolism; Pharmacology/Toxicology; Phosphorylation; Proto-Oncogene Proteins c-akt - metabolism; Pulmonary Edema - prevention & control; RAW 264.7 Cells; Rodents; Traditional Chinese medicine; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; Vaccine; NO; macrophages; lipopolysaccharides; iNOS; AKT; pro-inflammatory cytokine; protostemonine; acute lung injury; MAPKs