Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

• Published in: Heliyon Vol. 8; no. 6; p. e09787
• Main Authors: Sri Rethinavel, Harini, Selvaraj, Divya Bharathi, Balakrishnan, Sathya Jeevitha, Vergil Andrews, Jemi Feiona, Joseph, Jerly Helan Mary, Kandasamy, Mahesh
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.06.2022; Elsevier
• Subjects: animal models; Anxiety; brain; cysteamine; Cysteamine hydrochloride; decline; Elevated plus maze; gastrointestinal system; mice; neuroplasticity; Omeprazole; Open field test; Proton pump inhibitor; proton pump inhibitors; tranquilizers; Omeprazole; Cysteamine hydrochloride; Anxiety; Open field test; Elevated plus maze; Proton pump inhibitor
• DOI: 10.1016/j.heliyon.2022.e09787
• ISSN: 2405-8440

Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI disorders have been known to be associated with anxiety. In recent years, an exponentially increased number of subjects with abnormal ageing, neurological deficits, and psychiatric problems simultaneously exhibit GI dysfunctions as well as anxiety. Considering the fact, drugs that are used to treat GI disorders can be speculated to mitigate anxiety-related symptoms, and vice versa. Although, omeprazole treatment has been reported to result in development of anxiety and neurocognitive decline, ample reports suggest that omeprazole treatment is beneficial for the positive regulation of neuroplasticity. While underlying mechanisms of omeprazole-mediated neurological alterations remain obscure, the available scientific data on the omeprazole induced adverse effects in the brain appear to be inadequate, uncertain, and controversial. Hence, this study revisited the effect of omeprazole treatment on the degree of anxiety-like behaviours in a cysteamine hydrochloride (HCl) induced mouse model of GI disorder using open field test (OFT), light-dark box (LDB) test and elevated plus maze (EPM). Results revealed that omeprazole treatment mitigates anxiety-related behaviours in the cysteamine HCl induced animal model of GI disorder. Thus, this study assuredly supports and validates the anxiolytic properties of omeprazole. However, the adverse effects associated with inappropriate intake of omeprazole may not completely be excluded. Therefore, this study advocates the future direction in determining the long-term effects of omeprazole on the brain functions. Omeprazole; Anxiety; Open field test; Elevated plus maze; Proton pump inhibitor; Cysteamine hydrochloride.