WGE: a CRISPR database for genome engineering

• Published in: Bioinformatics Vol. 31; no. 18; pp. 3078 - 3080
• Main Authors: Hodgkins, Alex, Farne, Anna, Perera, Sajith, Grego, Tiago, Parry-Smith, David J, Skarnes, William C, Iyer, Vivek
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 15.09.2015
• Subjects: Animals; Applications Notes; Bioinformatics; Clustered Regularly Interspaced Short Palindromic Repeats - genetics; CRISPR-Cas Systems - genetics; Databases, Factual; Editing; Gene Expression Regulation; Genes; Genetic Vectors; Genome; Genomes; Humans; Mice; Online; RNA Editing - genetics; Scoring; Software; Translations

The rapid development of CRISPR-Cas9 mediated genome editing techniques has given rise to a number of online and stand-alone tools to find and score CRISPR sites for whole genomes. Here we describe the Wellcome Trust Sanger Institute Genome Editing database (WGE), which uses novel methods to compute...