Demonstration of in vivo transfer of doxycycline resistance mediated by a novel transposon

• Published in: Journal of antimicrobial chemotherapy Vol. 60; no. 5; pp. 973 - 980
• Main Authors: Warburton, Philip J., Palmer, Richard M., Munson, Mark A., Wade, William G.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.11.2007; Oxford Publishing Limited (England)
• Subjects: Anti-Bacterial Agents - pharmacology; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; antimicrobial resistance; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biological and medical sciences; Chemotherapy; Conjugation, Genetic; Dental research; DNA Transposable Elements - genetics; DNA, Bacterial - genetics; Doxycycline - pharmacology; Drug resistance; Drug Resistance, Bacterial - genetics; Erythromycin - pharmacology; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Gene Expression Regulation, Bacterial; Gum disease; Humans; Medical sciences; Non tumoral diseases; Otorhinolaryngology. Stomatology; Periodontal Diseases - microbiology; periodontitis; Pharmacology. Drug treatments; Phylogeny; Streptococcal Infections - microbiology; Streptococcus - drug effects; Streptococcus - genetics; Streptococcus oralis; Streptococcus sanguinis; tetracycline; transposon; transposon; tetracycline; antimicrobial resistance; periodontitis; Drug susceptibility test; Stomatology; Transposon; Tetracycline derivatives; Transposable element; Antimicrobial agent; Resistance; In vivo; Periodontal disease; Antibiotic; Periodontitis; Doxycycline; Transfer; Protein synthesis inhibitor; Antibacterial agent

Objectives The aim of this study was to investigate the transfer of bacterial doxycycline resistance between oral bacteria in subjects receiving systemic doxycycline for the treatment of periodontitis. Patients and methods Streptococci were cultured before and after treatment from the subgingival pl...