Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease

• Published in: Aging cell Vol. 19; no. 10; pp. e13239 - n/a
• Main Authors: Zhao, Yue, Zeng, Chen‐Ye, Li, Xiao‐Hong, Yang, Ting‐Ting, Kuang, Xi, Du, Jun‐Rong
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2020; John Wiley and Sons Inc
• Subjects: Advertising executives; Alzheimer's disease; Amyloid precursor protein; Aβ clearance; Brain; Cerebrospinal fluid; Choroid plexus; Cognition & reasoning; Cognitive ability; Dementia disorders; Epithelial cells; Hypotheses; Klotho; Klotho protein; Microglia; Neurodegenerative diseases; Neurons; Neuroprotection; Original; Pathogenesis; Peptides; Presenilin 1; Proteins; Senile plaques; Statistical analysis; Target marketing; Variance analysis; Ventricle; Ventricles (cerebral); Klotho; Alzheimer's disease; Aβ clearance

Alzheimer's disease (AD) is the most prevalent type of dementia, characterized by the presence of amyloid‐β (Aβ) plaques. We previously reported that Klotho lowered Aβ levels in the brain and protected against cognitive deficits in amyloid precursor protein/presenilin 1(APP/PS1) mice. However,...