Hemodynamics and Salt-and-Water Balance Link Sodium Storage and Vascular Dysfunction in Salt-Sensitive Subjects

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 68; no. 1; pp. 195 - 203
• Main Authors: Laffer, Cheryl L., Scott, Robert C., Titze, Jens M., Luft, Friedrich C., Elijovich, Fernando
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.07.2016
• Subjects: Adult; Black or African American - statistics & numerical data; Blood Pressure - physiology; Blood Pressure Determination; Female; Hemodynamics - physiology; Humans; Male; Middle Aged; Prospective Studies; Salt Tolerance; Sampling Studies; Sensitivity and Specificity; Sodium Chloride, Dietary - administration & dosage; Vascular Resistance - physiology; Water-Electrolyte Balance - physiology; blood pressure; sodium; hemodynamics; body water

We investigated 24-hour hemodynamic changes produced by salt loading and depletion in 8 salt-sensitive (SS) and 13 salt-resistant (SR) normotensive volunteers. After salt loading, mean arterial pressure was higher in SS (96.5±2.8) than in SR (84.2±2.7 mm Hg), P<0.01, owing to higher total periphe...