Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans

• Published in: Circulation (New York, N.Y.) Vol. 134; no. 8; pp. 611 - 624
• Main Authors: van der Valk, Fleur M., Bekkering, Siroon, Kroon, Jeffrey, Yeang, Calvin, Van den Bossche, Jan, van Buul, Jaap D., Ravandi, Amir, Nederveen, Aart J., Verberne, Hein J., Scipione, Corey, Nieuwdorp, Max, Joosten, Leo A.B., Netea, Mihai G., Koschinsky, Marlys L., Witztum, Joseph L., Tsimikas, Sotirios, Riksen, Niels P., Stroes, Erik S.G.
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 23.08.2016
• Subjects: Adult; Aged; Aorta - diagnostic imaging; Aorta - metabolism; Cell Movement - physiology; Cells, Cultured; Female; Humans; Inflammation - diagnostic imaging; Inflammation - metabolism; Inflammation Mediators - metabolism; Leukocytes, Mononuclear - metabolism; Lipoprotein(a) - metabolism; Male; Middle Aged; Phospholipids - metabolism; Positron Emission Tomography Computed Tomography; atherosclerosis; monocytes; lipoproteins

BACKGROUND:Elevated lipoprotein(a) [Lp(a)] is a prevalent, independent cardiovascular risk factor, but the underlying mechanisms responsible for its pathogenicity are poorly defined. Because Lp(a) is the prominent carrier of proinflammatory oxidized phospholipids (OxPLs), part of its atherothrombosi...