Head‐up tilt does not enhance prostate tumor perfusion or oxygenation in young rats

• Published in: Physiological reports Vol. 10; no. 24; pp. e15548 - n/a
• Main Authors: Kunkel, Olivia N., Rand, Taylor A., Pyle, Joseph G., Baumfalk, Dryden R., Horn, Andrew G., Opoku‐Acheampong, Alexander B., Ade, Carl J., Musch, Timothy I., Ramsey, Michael W., Delp, Michael D., Behnke, Bradley J.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2022; John Wiley and Sons Inc; Wiley
• Subjects: Abdomen; Adenocarcinoma; Animals; Blood; Blood flow; Blood Pressure - physiology; Cancer therapies; Carotid arteries; Catheters; Feeds; Heart; Heart Rate - physiology; Hemodynamics; Humans; Hypoxia; Laboratory animals; Male; Original; Oxygenation; Perfusion; Posture; Pressure; Prostate cancer; Prostatic Neoplasms; Radiation therapy; Rats; Retrospective Studies; Solid tumors; tilt; tumor blood flow; Tumors; Veins & arteries

Solid tumors contain hypoxic regions that contribute to anticancer therapy resistance. Thus, mitigating tumor hypoxia may enhance the efficacy of radiation therapy which is commonly utilized for patients with prostate cancer. Increasing perfusion pressure in the prostate with head‐up tilt (HUT) may...