Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus

• Published in: Aging cell Vol. 20; no. 2; pp. e13277 - n/a
• Main Authors: Kodali, Maheedhar, Attaluri, Sahithi, Madhu, Leelavathi N., Shuai, Bing, Upadhya, Raghavendra, Gonzalez, Jenny Jaimes, Rao, Xiaolan, Shetty, Ashok K.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2021; John Wiley and Sons Inc
• Subjects: activated microglia; Adenosine kinase; Aging; Alzheimer's disease; AMP; Analysis; Animal behavior; Animal cognition; Autophagy; Brain; Cognitive ability; cognitive function; Cytokines; Dementia; Dementia disorders; Diabetes; Diabetes mellitus; Diabetes therapy; Drinking water; Executive function; Health aspects; Hippocampus; Hypertrophy; Inflammation; Insulin; Kinases; Life span; Memory; Metformin; Mice; Microglia; Middle age; Neurogenesis; neuroinflammation; Original Paper; Phagocytosis; Phenotypes; Phosphorylation; Protein kinase; Rapamycin; TOR protein; Type 2 diabetes; Young adults; cognitive function; neurogenesis; metformin; activated microglia; neuroinflammation

Ten weeks of metformin treatment in late middle age is efficacious for improving cognitive function in the old age. Improved cognitive function following metformin treatment was linked with antiinflammatory effects, the activation of adenosine monophosphate‐activated protein kinase (AMPK), the mamma...