Polymer-based monolithic column with incorporated chiral metal-organic framework for enantioseparation of methyl phenyl sulfoxide using nano-liquid chromatography
A new approach to the preparation of enantioselective porous polymer monolithic columns with incorporated chiral metal–organic framework for nano‐liquid chromatography has been developed. While no enantioseparation was achieved with monolithic poly(4‐vinylpyridine‐co‐ethylene dimethacrylate) column,...
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Published in | Journal of separation science Vol. 39; no. 23; pp. 4544 - 4548 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Blackwell Publishing Ltd
01.12.2016
Wiley Subscription Services, Inc Wiley Blackwell (John Wiley & Sons) |
Subjects | |
Online Access | Get full text |
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Summary: | A new approach to the preparation of enantioselective porous polymer monolithic columns with incorporated chiral metal–organic framework for nano‐liquid chromatography has been developed. While no enantioseparation was achieved with monolithic poly(4‐vinylpyridine‐co‐ethylene dimethacrylate) column, excellent separations of both enantiomers of (±)‐methyl phenyl sulfoxide were achieved with its counterpart prepared after admixing metal–organic framework [Zn2(benzene dicarboxylate)(l‐lactic acid)(dmf)], which is synthesized from zinc nitrate, l‐lactic acid, and benzene dicarboxylic acid in the polymerization mixture. These novel monolithic columns combined selectivity of the chiral framework with the excellent hydrodynamic properties of polymer monoliths, may provide a great impact on future studies in the field of chiral analysis by liquid chromatography. |
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Bibliography: | National Natural Science Foundation of China - No. 2152780016, 21175008 Figure S1. XRD patterns of chiral MOF formulated as [Zn2(bdc)(L-lac)(dmf)](DMF): (A) simulated, and (B) synthesized. Figure S2. The dead time of poly(VP-EDMA) monolithic column (A) and poly(VP-EDMA-chiral MOF) monolithic column (B). Figure S3. Nano-LC chromatograms of (±)-methyl phenyl sulfoxide separated using poly(VP-EDMA-chiral MOF) (A) and poly(VP-EDMA) monolithic columns (B). Conditions: Column: 30 cm x 100 mm i.d.; Mobile phase: hexane/isopropanol 97:3 (v/v); Flow rate 1 μL/min; Column temperature 20 oC; Concentration of sulfoxide was 5 mg/mL dissolved in mobile phase; Injection volume 100 nL. Figure S4. Effect of sample loading on the separation of (±)-methyl phenyl sulfoxide enantiomers. Injections: 500 ng (100 nL, 5 mg/mL) (A), 750 ng (150 nL, 5 mg/mL) (B), 1000 ng (200 nL, 5 mg/mL) (C), 1500 ng (300 nL, 5 mg/mL) (D), 2000 ng (400 nL, 5 mg/mL) (E). Figure S5. A linear increase of chromatographic peak area with increasing mass of methyl phenyl sulfoxide from 0.5 to 2.0 μg. ArticleID:JSSC5154 istex:0C0FC3EACF2696F106F3784B79730AD272C7F78A U.S. Department of Energy - No. DE-AC02-05CH11231 Office of Science ark:/67375/WNG-K5CP6WDL-J Additional correspondence: Dr. Frantisek Svec E‐mail fsvec@lbl.gov : ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 DE‐AC02‐05CH11231 USDOE |
ISSN: | 1615-9306 1615-9314 |
DOI: | 10.1002/jssc.201600810 |