JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function

• Published in: Circulation research Vol. 127; no. 8; pp. 1056 - 1073
• Main Authors: Kakogiannos, Nikolaos, Ferrari, Laura, Giampietro, Costanza, Scalise, Anna Agata, Maderna, Claudio, Ravà, Micol, Taddei, Andrea, Lampugnani, Maria Grazia, Pisati, Federica, Malinverno, Matteo, Martini, Emanuele, Costa, Ilaria, Lupia, Michela, Cavallaro, Ugo, Beznoussenko, Galina V., Mironov, Alexander A., Fernandes, Bethania, Rudini, Noemi, Dejana, Elisabetta, Giannotta, Monica
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 25.09.2020; Lippincott Williams & Wilkins
• Subjects: claudin-5; endothelium; junctional adhesion molecule A; Original Research; tight junctions; vascular permeability; endothelium; tight junctions; vascular permeability; junctional adhesion molecule A; claudin-5

RATIONALE:Intercellular tight junctions are crucial for correct regulation of the endothelial barrier. Their composition and integrity are affected in pathological contexts, such as inflammation and tumor growth. JAM-A (junctional adhesion molecule A) is a transmembrane component of tight junctions...