Formation of fibroblastic reticular network in the brain after infection with neurovirulent murine coronavirus

• Published in: Neuropathology Vol. 36; no. 6; pp. 513 - 526
• Main Authors: Watanabe, Rihito, Kakizaki, Masatoshi, Ikehara, Yuzuru, Togayachi, Akira
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.12.2016; Wiley Subscription Services, Inc; John Wiley and Sons Inc
• Subjects: Animals; blood-brain barrier; Brain - pathology; Brain - virology; CD11b; Collagen; Coronaviridae; Coronavirus Infections - pathology; Coronavirus Infections - virology; extracellular matrix; fibroblastic reticular cell; Fibroblasts - pathology; Fibroblasts - virology; Infections; Mice; Mice, Inbred BALB C; Murine hepatitis virus - pathogenicity; Original; reticular fiber; Virulence; blood-brain barrier; reticular fiber; CD11b; extracellular matrix; fibroblastic reticular cell

cl‐2 virus is an extremely neurovirulent murine coronavirus. However, during the initial phase of infection between 12 and 24 h post‐inoculation (hpi), the viral antigens are detected only in the meninges, followed by viral spread into the ventricular wall before invasion into the brain parenchyma,...