Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis

• Published in: Aging cell Vol. 20; no. 2; pp. e13301 - n/a
• Main Authors: Li, Qiangqiang, Cheng, Jack Chun‐yiu, Jiang, Qing, Lee, Wayne Yuk‐wai
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2021; John Wiley and Sons Inc
• Subjects: Adenine; Adenosine triphosphate; Age; Aging; Animals; B cells; Bone and Bones - metabolism; Bone density; Bone diseases; Bone mass; Bone remodeling; Bone strength; Bone turnover; Cytokines; Development and progression; Fractures; Genetic engineering; Health aspects; Homeostasis; Humans; Immobilization; Medical research; Medicine, Experimental; NAD; Niacinamide; Osteoporosis; Osteoporosis - drug therapy; Osteoporosis - metabolism; Oxidative stress; Post-menopause; Postmenopausal women; Proteins; Review; Reviews; Senescence; SIRT1 protein; Sirtuins; Sirtuins - metabolism; Tumor necrosis factor-TNF; bone remodeling; aging; osteoporosis; sirtuins

The decline in bone mass and bone strength and musculoskeletal problems associated with aging constitute a major challenge for affected individuals and the healthcare system globally. Sirtuins 1‐7 (SIRT1‐SIRT7) are a family of nicotinamide adenine dinucleotide‐dependent deacetylases with remarkable...