Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis

The decline in bone mass and bone strength and musculoskeletal problems associated with aging constitute a major challenge for affected individuals and the healthcare system globally. Sirtuins 1‐7 (SIRT1‐SIRT7) are a family of nicotinamide adenine dinucleotide‐dependent deacetylases with remarkable...

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Published inAging cell Vol. 20; no. 2; pp. e13301 - n/a
Main Authors Li, Qiangqiang, Cheng, Jack Chun‐yiu, Jiang, Qing, Lee, Wayne Yuk‐wai
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.02.2021
John Wiley and Sons Inc
Subjects
Adenine
Adenosine triphosphate
Age
Aging
Animals
B cells
Bone and Bones - metabolism
Bone density
Bone diseases
Bone mass
Bone remodeling
Bone strength
Bone turnover
Cytokines
Development and progression
Fractures
Genetic engineering
Health aspects
Homeostasis
Humans
Immobilization
Medical research
Medicine, Experimental
NAD
Niacinamide
Osteoporosis
Osteoporosis - drug therapy
Osteoporosis - metabolism
Oxidative stress
Post-menopause
Postmenopausal women
Proteins
Review
Reviews
Senescence
SIRT1 protein
Sirtuins
Sirtuins - metabolism
Tumor necrosis factor-TNF
bone remodeling
aging
osteoporosis
sirtuins
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Abstract The decline in bone mass and bone strength and musculoskeletal problems associated with aging constitute a major challenge for affected individuals and the healthcare system globally. Sirtuins 1‐7 (SIRT1‐SIRT7) are a family of nicotinamide adenine dinucleotide‐dependent deacetylases with remarkable abilities to promote longevity and counteract age‐related diseases. Sirtuin knockout and transgenic models have provided novel insights into the function and signaling of these proteins in bone homeostasis. Studies have revealed that sirtuins play a critical role in normal skeletal development and homeostasis through their direct action on bone cells and that their dysregulation might contribute to different bone diseases. Preclinical studies have demonstrated that mice treated with sirtuin agonists show protection against age‐related, postmenopausal, and immobilization‐induced osteoporosis. These findings suggest that sirtuins could be potential targets for the modulation of the imbalance in bone remodeling and treatment of osteoporosis and other bone disorders. The aim of this review was to provide a comprehensive updated review of the current knowledge on sirtuin biology, focusing specifically on their roles in bone homeostasis and osteoporosis, and potential pharmacological interventions targeting sirtuins for the treatment of osteoporosis. Sirtuins (SIRT1–SIRT7) are a family of nicotinamide adenine dinucleotide (NAD+)‐dependent deacetylases with remarkable abilities to promote longevity and counteract age‐related diseases. Sirtuins play diverse roles in bone homeostasis through actions on various cell types in bone tissues. Preclinical and clinical evidence have demonstrated the link between sirtuins and osteoporosis. Modulation of sirtuins could be potential strategies for the treatment of osteoporosis and other aging‐related bone disorders.
AbstractList The decline in bone mass and bone strength and musculoskeletal problems associated with aging constitute a major challenge for affected individuals and the healthcare system globally. Sirtuins 1‐7 (SIRT1‐SIRT7) are a family of nicotinamide adenine dinucleotide‐dependent deacetylases with remarkable abilities to promote longevity and counteract age‐related diseases. Sirtuin knockout and transgenic models have provided novel insights into the function and signaling of these proteins in bone homeostasis. Studies have revealed that sirtuins play a critical role in normal skeletal development and homeostasis through their direct action on bone cells and that their dysregulation might contribute to different bone diseases. Preclinical studies have demonstrated that mice treated with sirtuin agonists show protection against age‐related, postmenopausal, and immobilization‐induced osteoporosis. These findings suggest that sirtuins could be potential targets for the modulation of the imbalance in bone remodeling and treatment of osteoporosis and other bone disorders. The aim of this review was to provide a comprehensive updated review of the current knowledge on sirtuin biology, focusing specifically on their roles in bone homeostasis and osteoporosis, and potential pharmacological interventions targeting sirtuins for the treatment of osteoporosis. Sirtuins (SIRT1–SIRT7) are a family of nicotinamide adenine dinucleotide (NAD+)‐dependent deacetylases with remarkable abilities to promote longevity and counteract age‐related diseases. Sirtuins play diverse roles in bone homeostasis through actions on various cell types in bone tissues. Preclinical and clinical evidence have demonstrated the link between sirtuins and osteoporosis. Modulation of sirtuins could be potential strategies for the treatment of osteoporosis and other aging‐related bone disorders.
The decline in bone mass and bone strength and musculoskeletal problems associated with aging constitute a major challenge for affected individuals and the healthcare system globally. Sirtuins 1‐7 (SIRT1‐SIRT7) are a family of nicotinamide adenine dinucleotide‐dependent deacetylases with remarkable abilities to promote longevity and counteract age‐related diseases. Sirtuin knockout and transgenic models have provided novel insights into the function and signaling of these proteins in bone homeostasis. Studies have revealed that sirtuins play a critical role in normal skeletal development and homeostasis through their direct action on bone cells and that their dysregulation might contribute to different bone diseases. Preclinical studies have demonstrated that mice treated with sirtuin agonists show protection against age‐related, postmenopausal, and immobilization‐induced osteoporosis. These findings suggest that sirtuins could be potential targets for the modulation of the imbalance in bone remodeling and treatment of osteoporosis and other bone disorders. The aim of this review was to provide a comprehensive updated review of the current knowledge on sirtuin biology, focusing specifically on their roles in bone homeostasis and osteoporosis, and potential pharmacological interventions targeting sirtuins for the treatment of osteoporosis.
The decline in bone mass and bone strength and musculoskeletal problems associated with aging constitute a major challenge for affected individuals and the healthcare system globally. Sirtuins 1-7 (SIRT1-SIRT7) are a family of nicotinamide adenine dinucleotide-dependent deacetylases with remarkable abilities to promote longevity and counteract age-related diseases. Sirtuin knockout and transgenic models have provided novel insights into the function and signaling of these proteins in bone homeostasis. Studies have revealed that sirtuins play a critical role in normal skeletal development and homeostasis through their direct action on bone cells and that their dysregulation might contribute to different bone diseases. Preclinical studies have demonstrated that mice treated with sirtuin agonists show protection against age-related, postmenopausal, and immobilization-induced osteoporosis. These findings suggest that sirtuins could be potential targets for the modulation of the imbalance in bone remodeling and treatment of osteoporosis and other bone disorders. The aim of this review was to provide a comprehensive updated review of the current knowledge on sirtuin biology, focusing specifically on their roles in bone homeostasis and osteoporosis, and potential pharmacological interventions targeting sirtuins for the treatment of osteoporosis.The decline in bone mass and bone strength and musculoskeletal problems associated with aging constitute a major challenge for affected individuals and the healthcare system globally. Sirtuins 1-7 (SIRT1-SIRT7) are a family of nicotinamide adenine dinucleotide-dependent deacetylases with remarkable abilities to promote longevity and counteract age-related diseases. Sirtuin knockout and transgenic models have provided novel insights into the function and signaling of these proteins in bone homeostasis. Studies have revealed that sirtuins play a critical role in normal skeletal development and homeostasis through their direct action on bone cells and that their dysregulation might contribute to different bone diseases. Preclinical studies have demonstrated that mice treated with sirtuin agonists show protection against age-related, postmenopausal, and immobilization-induced osteoporosis. These findings suggest that sirtuins could be potential targets for the modulation of the imbalance in bone remodeling and treatment of osteoporosis and other bone disorders. The aim of this review was to provide a comprehensive updated review of the current knowledge on sirtuin biology, focusing specifically on their roles in bone homeostasis and osteoporosis, and potential pharmacological interventions targeting sirtuins for the treatment of osteoporosis.
Audience Academic
Author Cheng, Jack Chun‐yiu
Lee, Wayne Yuk‐wai
Jiang, Qing
Li, Qiangqiang
AuthorAffiliation 4 Department of Sports Medicine and Adult Reconstructive Surgery Drum Tower Hospital affiliated to Medical School of Nanjing University Nanjing China
2 Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University The Chinese University of Hong Kong Hong Kong SAR China
3 Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Hong Kong SAR China
1 SH Ho Scoliosis Research Laboratory Department of Orthopaedics and Traumatology The Chinese University of Hong Kong Hong Kong SAR China
AuthorAffiliation_xml – name: 4 Department of Sports Medicine and Adult Reconstructive Surgery Drum Tower Hospital affiliated to Medical School of Nanjing University Nanjing China
– name: 2 Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University The Chinese University of Hong Kong Hong Kong SAR China
– name: 3 Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Hong Kong SAR China
– name: 1 SH Ho Scoliosis Research Laboratory Department of Orthopaedics and Traumatology The Chinese University of Hong Kong Hong Kong SAR China
Author_xml – sequence: 1
  givenname: Qiangqiang
  surname: Li
  fullname: Li, Qiangqiang
  organization: The Chinese University of Hong Kong
– sequence: 2
  givenname: Jack Chun‐yiu
  surname: Cheng
  fullname: Cheng, Jack Chun‐yiu
  organization: The Chinese University of Hong Kong
– sequence: 3
  givenname: Qing
  surname: Jiang
  fullname: Jiang, Qing
  organization: Drum Tower Hospital affiliated to Medical School of Nanjing University
– sequence: 4
  givenname: Wayne Yuk‐wai
  orcidid: 0000-0002-0486-360X
  surname: Lee
  fullname: Lee, Wayne Yuk‐wai
  email: waynelee@ort.cuhk.edu.hk
  organization: The Chinese University of Hong Kong
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33393735$$D View this record in MEDLINE/PubMed
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Issue 2
Keywords bone remodeling
aging
osteoporosis
sirtuins
Language English
License Attribution
2021 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Notes Funding information
This work was supported by the General Research Fund, University Grants Committee, HKSAR (Ref No. 14163517 and 14120818 to WYW Lee), Health and Medical Research Fund, The Food and Health Bureau, The Government of the Hong Kong Special Adminstrative Region (Ref No 06170546 to WYW Lee), and Start‐up Fund, The Chinese University of Hong Kong, HKSAR (Ref No 4930991 to WYW Lee).
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Snippet The decline in bone mass and bone strength and musculoskeletal problems associated with aging constitute a major challenge for affected individuals and the...
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SubjectTerms Adenine
Adenosine triphosphate
Age
Aging
Animals
B cells
Bone and Bones - metabolism
Bone density
Bone diseases
Bone mass
Bone remodeling
Bone strength
Bone turnover
Cytokines
Development and progression
Fractures
Genetic engineering
Health aspects
Homeostasis
Humans
Immobilization
Medical research
Medicine, Experimental
NAD
Niacinamide
Osteoporosis
Osteoporosis - drug therapy
Osteoporosis - metabolism
Oxidative stress
Post-menopause
Postmenopausal women
Proteins
Review
Reviews
Senescence
SIRT1 protein
Sirtuins
Sirtuins - metabolism
Tumor necrosis factor-TNF
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Title Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Facel.13301
https://www.ncbi.nlm.nih.gov/pubmed/33393735
https://www.proquest.com/docview/2489336016
https://www.proquest.com/docview/2489349345
https://www.proquest.com/docview/2475094539
https://pubmed.ncbi.nlm.nih.gov/PMC7884050
Volume 20
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