CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 10; no. 10; pp. 2022 - 2028
• Main Authors: Lu, Na, Gao, Anran, Dai, Pengfei, Song, Shiping, Fan, Chunhai, Wang, Yuelin, Li, Tie
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 28.05.2014; Wiley Subscription Services, Inc
• Subjects: Base Pair Mismatch - genetics; Base Sequence; Biomarkers, Tumor - analysis; Biosensing Techniques - instrumentation; Biosensors; Cancer; Diagnosis; Electric Conductivity; Equipment Design; Equipment Failure Analysis; field-effect transistors (FETs); Human; Humans; label-free; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Medical research; microRNA; MicroRNAs; MicroRNAs - analysis; MicroRNAs - genetics; Molecular Sequence Data; Nanotechnology; Nanowires; Nanowires - chemistry; Nanowires - ultrastructure; Ovarian cancer; Prognosis; Reproducibility of Results; Ribonucleic acids; Sensitivity and Specificity; Sensors; Sequence Analysis, RNA - methods; Silicon - chemistry; Staining and Labeling; Transistors, Electronic; Tumor Cells, Cultured; ultrasensitive; ultrasensitive; microRNA; label-free; sensors; nanowires; field-effect transistors (FETs)

MicroRNAs (miRNAs) have been regarded as promising biomarkers for the diagnosis and prognosis of early‐stage cancer as their expression levels are associated with different types of human cancers. However, it is a challenge to produce low‐cost miRNA sensors, as well as retain a high sensitivity, bot...