Removal of the ovaries suppresses ethanol drinking and promotes aversion-resistance in C57BL/6J female mice

• Published in: Psychopharmacology Vol. 240; no. 12; pp. 2607 - 2616
• Main Authors: Sneddon, Elizabeth A., Masters, Brianna M., Shi, Haifei, Radke, Anna K.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2023; Springer; Springer Nature B.V
• Subjects: Addictive behaviors; Alcohol; Alcohol Drinking; Alcohol, Denatured; Animals; Aversion; Aversion therapy; Biomedical and Life Sciences; Biomedicine; Complications and side effects; Demographic aspects; Drinking behavior; Ethanol; Ethanol - pharmacology; Female; Health aspects; Hormones; Humans; Male; Mice; Mice, Inbred C57BL; Neurosciences; Original Investigation; Ovariectomy; Ovaries; Ovary; Patient outcomes; Pharmacology/Toxicology; Psychiatry; Psychological aspects; Quinine; Surgery; Women; United States; Alcohol consumption; Frontloading; Ethanol; Mouse; Ovarian hormones; Preference; Aversion-resistant; Female; Quinine; Drinking in the dark

Rationale Female rodents consume more ethanol (EtOH) than males and exhibit greater aversion-resistant drinking in some paradigms. Ovarian hormones promote EtOH drinking but the contribution of ovarian hormones to aversion-resistant drinking has not been assessed. Objectives We aimed to investigate...