Gut microbiota induce IGF-1 and promote bone formation and growth

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 47; pp. E7554 - E7563
• Main Authors: Yan, Jing, Herzog, Jeremy W., Tsang, Kelly, Brennan, Caitlin A., Bower, Maureen A., Garrett, Wendy S., Sartor, Balfour R., Aliprantis, Antonios O., Charles, Julia F.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.11.2016
• Series: PNAS Plus
• Subjects: Adipose tissue; Antibiotics; Biological Sciences; Colonization; Fatty acids; Homeostasis; Insulin-like growth factors; Metabolism; Metabolites; Microorganisms; PNAS Plus; microbiota; IGF-1; bone; SCFA

Appreciation of the role of the gut microbiome in regulating vertebrate metabolism has exploded recently. However, the effects of gut microbiota on skeletal growth and homeostasis have only recently begun to be explored. Here, we report that colonization of sexually mature germ-free (GF) mice with c...