Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study

• Published in: The Lancet (British edition) Vol. 371; no. 9618; pp. 1108 - 1113
• Main Authors: von Gottberg, Anne, FCPath [SA] Micro, Klugman, Keith P, Prof, Cohen, Cheryl, FCPath [SA] Micro, Wolter, Nicole, PhD, de Gouveia, Linda, MT, du Plessis, Mignon, PhD, Mpembe, Ruth, MT, Quan, Vanessa, MBBCh, Whitelaw, Andrew, FCPath [SA] Micro, Hoffmann, Rena, MMed, Govender, Nelesh, FCPath [SA] Micro, Meiring, Susan, MBChB, Smith, Anthony M, PhD, Schrag, Stephanie, DPhil
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 29.03.2008; Elsevier Limited
• Subjects: Adolescent; Anti-Bacterial Agents - therapeutic use; Antitubercular Agents - therapeutic use; Child; Child, Preschool; Children & youth; Cross Infection; Cross-Sectional Studies; Diagnostic tests; Drug resistance; Drug Resistance, Bacterial - drug effects; Female; Hospitals; Humans; Infant; Infections; Internal Medicine; Laboratories; Levofloxacin; Male; Mycobacterium; Nosocomial infection; Ofloxacin - therapeutic use; Patients; Pneumococcal Infections - drug therapy; Pneumococcal Infections - epidemiology; Pneumonia; Population Surveillance; Rifampin - therapeutic use; Risk Factors; South Africa - epidemiology; Statistics, Nonparametric; Streptococcus infections; Streptococcus pneumoniae; Streptococcus pneumoniae - drug effects; Streptococcus pneumoniae - pathogenicity; Tuberculosis; Tuberculosis, Multidrug-Resistant - drug therapy; World Health Organization; South Africa

Summary Background Use of fluoroquinolones to treat paediatric cases of multidrug-resistant tuberculosis could affect the emergence of resistance to this class of drugs. Our aim was to estimate the incidence of, and risk factors for, invasive pneumococcal disease caused by fluoroquinolone-resistant...