Altered metabotropic glutamate receptor 5 markers in PTSD In vivo and postmortem evidence

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 31; pp. 8390 - 8395
• Main Authors: Holmes, Sophie E., Girgenti, Matthew J., Davis, Margaret T., Pietrzak, Robert H., DellaGioia, Nicole, Nabulsi, Nabeel, Matuskey, David, Southwick, Steven, Duman, Ronald S., Carson, Richard E., Krystal, John H., Esterlis, Irina
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 01.08.2017
• Subjects: Aberration; Adult; Anchors; Availability; Base Sequence; Biological Sciences; Cell surface; Cortex; Drug therapy; Female; Gene Expression - physiology; Glucocorticoids; Glucocorticoids - metabolism; Glutamic Acid - metabolism; Glutamic acid receptors (metabotropic); Humans; Male; Molecular modelling; Nerve Tissue Proteins - biosynthesis; Neurons; Pharmacology; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Post traumatic stress disorder; Protein expression; Proteins; Psychopathology; Radiopharmaceuticals - pharmacology; Receptor, Metabotropic Glutamate 5 - metabolism; Sequence Analysis, RNA; Signal transduction; Stress Disorders, Post-Traumatic - drug therapy; Stress Disorders, Post-Traumatic - pathology; Tacrolimus Binding Proteins - biosynthesis; Tomography; Trauma; PTSD; glucocorticoid; RNA; PET; glutamate

Posttraumatic stress disorder (PTSD) is a prevalent and highly disabling disorder, but there is currently no targeted pharmacological treatment for it. Dysfunction of the glutamate system has been implicated in trauma and stress psychopathology, resulting in a growing interest in modulation of the g...