Relationship Between Adrenomedullin, Metabolic Factors, and Vascular Function in Individuals With Type 2 Diabetes

• Published in: Diabetes care Vol. 30; no. 6; pp. 1513 - 1519
• Main Authors: Lim, Su Chi, Morgenthaler, Nils G, Subramaniam, Tavintharan, Wu, Yew Seng, Goh, Siew Kheng, Sum, Chee Fang
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2007
• Subjects: adiponectin; Adrenomedullin; Adrenomedullin - blood; Adult; Associated diseases and complications; Biological and medical sciences; blood; Blood circulation disorders; blood glucose; Blood Pressure; Blood Vessels; Blood Vessels - physiopathology; Body Mass Index; C-reactive protein; Circulatory system; Complications and side effects; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies; Diabetic Angiopathies - blood; Diabetic Angiopathies - physiopathology; Diabetic Nephropathies; Diabetic Nephropathies - blood; Diabetic Nephropathies - physiopathology; diabetic nephropathy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; fasting; Female; glucose; Glucose Intolerance; Glucose Intolerance - blood; Glucose Intolerance - physiopathology; Hormones; Humans; Hyperglycemia; insulin resistance; Kidney diseases; Kidneys; linear models; low density lipoprotein cholesterol; Male; Medical sciences; Metabolism; Middle Aged; Miscellaneous; Nephrology. Urinary tract diseases; noninsulin-dependent diabetes mellitus; pathogenesis; physiopathology; Protein Precursors; Protein Precursors - blood; Proteins; Public health. Hygiene; Public health. Hygiene-occupational medicine; Reference Values; regression analysis; risk; Risk factors; Studies; Type 2 diabetes; Urinary system involvement in other diseases. Miscellaneous; United States; Endocrinopathy; Kidney disease; Type 2 diabetes; Human; Urinary system disease; Pathogenesis; Diabetes mellitus; Adrenomedullin; Metabolic diseases; Concomitant disease; Nephropathy; Blood vessel; Diabetic nephropathy; Circulatory system

OBJECTIVE:--Subjects with type 2 diabetes are at risk for vascular injury. Several vasoactive factors (e.g., angiotensin) have been implicated. We hypothesize that adrenomedullin, a novel vascoactive factor, is deranged in subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS--Using a new immun...