Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma
Purpose The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades. Materials and Methods Twenty-four human papillary carcinoma tissu...
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| Published in | Nuclear medicine and molecular imaging Vol. 48; no. 2; pp. 91 - 97 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.06.2014
대한핵의학회 |
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| Abstract | Purpose
The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades.
Materials and Methods
Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n = 13) and relatively less differentiated group (n = 11).
Results
Glut-1 gene expression was significantly higher in the less differentiated group (0.66 ± 0.04) than in the well-differentiated group (0.59 ± 0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67 ± 0.20, PD: 0.65 ± 0.21, TG: 0.74 ± 0.16) than in the less differentiated group (NIS: 0.36 ± 0.05, PD: 0.49 ± 0.08, TG: 0.60 ± 0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD.
Conclusion
The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy. |
|---|---|
| AbstractList | Purpose
The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades.
Materials and Methods
Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n = 13) and relatively less differentiated group (n = 11).
Results
Glut-1 gene expression was significantly higher in the less differentiated group (0.66 ± 0.04) than in the well-differentiated group (0.59 ± 0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67 ± 0.20, PD: 0.65 ± 0.21, TG: 0.74 ± 0.16) than in the less differentiated group (NIS: 0.36 ± 0.05, PD: 0.49 ± 0.08, TG: 0.60 ± 0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD.
Conclusion
The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy. PURPOSEThe expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades.MATERIALS AND METHODSTwenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n = 13) and relatively less differentiated group (n = 11).RESULTSGlut-1 gene expression was significantly higher in the less differentiated group (0.66 ± 0.04) than in the well-differentiated group (0.59 ± 0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67 ± 0.20, PD: 0.65 ± 0.21, TG: 0.74 ± 0.16) than in the less differentiated group (NIS: 0.36 ± 0.05, PD: 0.49 ± 0.08, TG: 0.60 ± 0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD.CONCLUSIONThe NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy. Purpose The expression of glucose transporter-1 (Glut-1)gene and those of major thyroid-specific genes were examinedin papillary carcinoma tissues, and the expressions of thesegenes were compared with cancer differentiation grades. Materials and Methods Twenty-four human papillary carcinomatissues were included in this study. The expressions ofGlut-1- and thyroid-specific genes [sodium/iodide symporter(NIS), thyroid peroxidase, thyroglobulin, TSH receptor andpendrin] were analyzed by RT-PCR. Expression levels wereexpressed as ratios versus the expression of beta-actin. Pathologicdifferentiation of papillary carcinoma was classifiedinto a relatively well-differentiated group (n=13) and relativelyless differentiated group (n=11). Results Glut-1 gene expression was significantly higher in theless differentiated group (0.66±0.04) than in the welldifferentiatedgroup (0.59±0.07). The expression levels of theNIS, PD and TG genes were significantly higher in the welldifferentiatedgroup (NIS: 0.67±0.20, PD: 0.65±0.21, TG:0.74±0.16) than in the less differentiated group (NIS: 0.36±0.05, PD: 0.49±0.08, TG: 0.60±0.11), respectively. A significantnegative correlation was found between Glut-1 and NISexpression, and positive correlations were found between NISand TG, and between NIS and PD. Conclusion The NIS, PD and TG genes were highly expressedin well-differentiated thyroid carcinomas, whereasthe Glut-1 gene was highly expressed in less differentiatedthyroid carcinomas. These findings provide a molecular rationalefor the management of papillary carcinoma, especially inthe selection of FDG PETor radioiodine whole-body scan andI-131-based therapy. KCI Citation Count: 6 The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades. Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n = 13) and relatively less differentiated group (n = 11). Glut-1 gene expression was significantly higher in the less differentiated group (0.66 ± 0.04) than in the well-differentiated group (0.59 ± 0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67 ± 0.20, PD: 0.65 ± 0.21, TG: 0.74 ± 0.16) than in the less differentiated group (NIS: 0.36 ± 0.05, PD: 0.49 ± 0.08, TG: 0.60 ± 0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD. The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy. |
| Author | Lee, Dong Soo Park, Sung-Hwae Kim, Sungeun Kang, Joo-Hyun Park, Do Joon Lee, Sinae Chung, June-Key Lee, Myung Chul Min, Hae-Sook Cho, Bo Youn Jeong, Jae Min |
| Author_xml | – sequence: 1 givenname: Sungeun surname: Kim fullname: Kim, Sungeun organization: Departments of Nuclear Medicine, Seoul National University College of Medicine, Departments of Nuclear Medicine, Korea University College of Medicine – sequence: 2 givenname: June-Key surname: Chung fullname: Chung, June-Key email: jkchung@plaza.snu.ac.kr organization: Departments of Nuclear Medicine, Seoul National University College of Medicine, Cancer Research Institute, Seoul National University College of Medicine, Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul National University Hospital – sequence: 3 givenname: Hae-Sook surname: Min fullname: Min, Hae-Sook organization: Departments of Pathology, Seoul National University College of Medicine – sequence: 4 givenname: Joo-Hyun surname: Kang fullname: Kang, Joo-Hyun organization: Departments of Nuclear Medicine, Seoul National University College of Medicine, Cancer Research Institute, Seoul National University College of Medicine, Tumor Immunity Medical Research Center, Seoul National University College of Medicine – sequence: 5 givenname: Do Joon surname: Park fullname: Park, Do Joon organization: Department of Internal Medicine, Seoul National University College of Medicine – sequence: 6 givenname: Jae Min surname: Jeong fullname: Jeong, Jae Min organization: Departments of Nuclear Medicine, Seoul National University College of Medicine, Cancer Research Institute, Seoul National University College of Medicine – sequence: 7 givenname: Dong Soo surname: Lee fullname: Lee, Dong Soo organization: Departments of Nuclear Medicine, Seoul National University College of Medicine – sequence: 8 givenname: Sung-Hwae surname: Park fullname: Park, Sung-Hwae organization: Departments of Pathology, Seoul National University College of Medicine – sequence: 9 givenname: Bo Youn surname: Cho fullname: Cho, Bo Youn organization: Department of Internal Medicine, Seoul National University College of Medicine – sequence: 10 givenname: Sinae surname: Lee fullname: Lee, Sinae organization: Departments of Nuclear Medicine, Korea University College of Medicine – sequence: 11 givenname: Myung Chul surname: Lee fullname: Lee, Myung Chul organization: Departments of Nuclear Medicine, Seoul National University College of Medicine |
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| Cites_doi | 10.1210/jcem.84.7.5827 10.1007/s00259-004-1475-3 10.1093/nar/15.16.6735 10.1111/j.1432-1033.1987.tb11466.x 10.1089/thy.2004.14.806 10.1203/00006450-200211000-00021 10.1210/jc.2003-030586 10.1016/0006-291X(89)92727-7 10.1111/j.1365-2559.1992.tb00963.x 10.1210/jcem.87.4.8372 10.1089/thy.1997.7.327 10.1089/thy.1998.8.385 10.1530/eje.0.1450129 10.1016/0304-4157(93)90017-I 10.1016/S0300-9084(99)80086-8 10.1007/978-3-642-61383-8 10.1007/s002590100509 10.1530/eje.0.1420340 10.1016/S0046-8177(97)90278-1 10.1089/thy.1997.7.363 10.1016/S0304-3835(03)00392-6 10.1089/105072502760339307 10.1097/00000478-198801000-00003 10.7326/0003-4819-115-2-133 10.1093/nar/12.3.1687 |
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| Keywords | Sodium/iodide symporter Thyroid peroxidase Thyroglobulin Papillary thyroid cancer Pendrin TSH receptor Glucose transporter-1 |
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The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the... The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the... PURPOSEThe expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the... Purpose The expression of glucose transporter-1 (Glut-1)gene and those of major thyroid-specific genes were examinedin papillary carcinoma tissues, and the... |
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| Title | Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma |
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