Abemaciclib and Vacuolin-1 decrease aggregate-prone TDP-43 accumulation by accelerating autophagic flux

• Published in: Biochemistry and biophysics reports Vol. 38; p. 101705
• Main Authors: Tanaka, Yoshinori, Kozuma, Lina, Hino, Hirotsugu, Takeya, Kosuke, Eto, Masumi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2024; Elsevier
• Subjects: Abemaciclib; Autophagic flux; PIP; TDP-43; Vacuolin-1; Abemaciclib; TDP-43; PIP; Vacuolin-1; Autophagic flux

(Macro)autophagy is a cellular degradation system for unnecessary materials, such as aggregate-prone TDP-43, a central molecule in neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Abemaciclib (Abe) and vacuolin-1 (Vac) treatments are known to...