Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase

• Published in: Toxicology and applied pharmacology Vol. 228; no. 1; pp. 32 - 41
• Main Authors: Yang, Dongren, Howard, Angela, Bruun, Donald, Ajua-Alemanj, Mispa, Pickart, Cecile, Lein, Pamela J.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.04.2008; Elsevier
• Subjects: 60 APPLIED LIFE SCIENCES; ACETYLCHOLINE; Acetylcholinesterase; Acetylcholinesterase - genetics; Acetylcholinesterase - physiology; Animals; Axonal growth; Axons - drug effects; Axons - metabolism; Axons - ultrastructure; Biological and medical sciences; Cell Survival - drug effects; Cells, Cultured; Chlorpyrifos; Chlorpyrifos - analogs & derivatives; Chlorpyrifos - toxicity; Cholinesterase Inhibitors - toxicity; Developmental neurotoxicity; Ganglia, Spinal - cytology; Ganglia, Spinal - drug effects; Ganglia, Spinal - growth & development; GENE REGULATION; Genes, Reporter - drug effects; Green Fluorescent Proteins - biosynthesis; Humans; HYDROLYSIS; IN VITRO; In vitro models; INHIBITION; Insecticides - toxicity; Medical sciences; MICE; Mice, Knockout; NERVE CELLS; Nerve Tissue Proteins - biosynthesis; NERVOUS SYSTEM; Neural Pathways - drug effects; Neurons, Afferent - drug effects; Neurons, Afferent - metabolism; Neurons, Afferent - ultrastructure; Organophosphates; Organophosphorus pesticides; PESTICIDES; Pesticides, fertilizers and other agrochemicals toxicology; PROTEINS; RATS; ROOTS; SYNTHESIS; Toxicology; Transfection; Chlorpyrifos; Axonal growth; In vitro models; Organophosphorus pesticides; Developmental neurotoxicity; Acetylcholinesterase; Organophosphates; Nervous system diseases; Insecticide; Enzyme; Growth; Toxicity; Pesticides; Nervous system; Esterases; In vitro; Biological activity; Carboxylic ester hydrolases; Neurotoxicity; Development; Hydrolases; Inhibitor; Models; Organophosphorus compounds

A primary role of acetylcholinesterase (AChE) is regulation of cholinergic neurotransmission by hydrolysis of synaptic acetylcholine. In the developing nervous system, however, AChE also functions as a morphogenic factor to promote axonal growth. This raises the question of whether organophosphorus...