Histopathological Lung Findings in COVID-19 B.1.617.2 SARS-CoV-2 Delta Variant
The Delta variant (Pango lineage B.1.617.2) is one of the most significant and aggressive variants of SARS-CoV-2. To the best of our knowledge, this is the first paper specifically studying pulmonary morphopathology in COVID-19 caused by the B.1.617.2 Delta variant. The study included 10 deceased pa...
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Published in | Journal of personalized medicine Vol. 13; no. 2; p. 279 |
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31.01.2023
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Abstract | The Delta variant (Pango lineage B.1.617.2) is one of the most significant and aggressive variants of SARS-CoV-2. To the best of our knowledge, this is the first paper specifically studying pulmonary morphopathology in COVID-19 caused by the B.1.617.2 Delta variant.
The study included 10 deceased patients (40-83 years) with the COVID-19 Delta variant. The necrotic lung fragments were obtained either by biopsy (six cases) or autopsy (four cases). Tissue samples were subjected to virology analysis for identification of the SARS-CoV-2 variant, histopathology, and immunohistochemistry (anti-SARS coronavirus mouse anti-virus antibody).
Virology analysis identified B.1.617.2 through genetic sequencing in eight cases, and in two cases, specific mutations of B.1.617.2 were identified. Macroscopically, in all autopsied cases, the lung had a particular appearance, purple in color, with increased consistency on palpation and abolished crepitations. Histopathologically, the most frequently observed lesions were acute pulmonary edema (70%) and diffuse alveolar damage at different stages. The immunohistochemical examination was positive for proteins of SARS-CoV-2 in 60% of cases on alveolocytes and in endothelial cells.
The histopathological lung findings in the B.1.617.2 Delta variant are similar to those previously described in COVID-19. Spike protein-binding antibodies were identified immunohistochemically both on alveolocytes and in the endothelial cells, showing the potential of indirect damage from thrombosis. |
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AbstractList | Background: The Delta variant (Pango lineage B.1.617.2) is one of the most significant and aggressive variants of SARS-CoV-2. To the best of our knowledge, this is the first paper specifically studying pulmonary morphopathology in COVID-19 caused by the B.1.617.2 Delta variant. Methods: The study included 10 deceased patients (40-83 years) with the COVID-19 Delta variant. The necrotic lung fragments were obtained either by biopsy (six cases) or autopsy (four cases). Tissue samples were subjected to virology analysis for identification of the SARS-CoV-2 variant, histopathology, and immunohistochemistry (anti-SARS coronavirus mouse anti-virus antibody). Results: Virology analysis identified B.1.617.2 through genetic sequencing in eight cases, and in two cases, specific mutations of B.1.617.2 were identified. Macroscopically, in all autopsied cases, the lung had a particular appearance, purple in color, with increased consistency on palpation and abolished crepitations. Histopathologically, the most frequently observed lesions were acute pulmonary edema (70%) and diffuse alveolar damage at different stages. The immunohistochemical examination was positive for proteins of SARS-CoV-2 in 60% of cases on alveolocytes and in endothelial cells. Conclusions: The histopathological lung findings in the B.1.617.2 Delta variant are similar to those previously described in COVID-19. Spike protein-binding antibodies were identified immunohistochemically both on alveolocytes and in the endothelial cells, showing the potential of indirect damage from thrombosis. The Delta variant (Pango lineage B.1.617.2) is one of the most significant and aggressive variants of SARS-CoV-2. To the best of our knowledge, this is the first paper specifically studying pulmonary morphopathology in COVID-19 caused by the B.1.617.2 Delta variant. The study included 10 deceased patients (40-83 years) with the COVID-19 Delta variant. The necrotic lung fragments were obtained either by biopsy (six cases) or autopsy (four cases). Tissue samples were subjected to virology analysis for identification of the SARS-CoV-2 variant, histopathology, and immunohistochemistry (anti-SARS coronavirus mouse anti-virus antibody). Virology analysis identified B.1.617.2 through genetic sequencing in eight cases, and in two cases, specific mutations of B.1.617.2 were identified. Macroscopically, in all autopsied cases, the lung had a particular appearance, purple in color, with increased consistency on palpation and abolished crepitations. Histopathologically, the most frequently observed lesions were acute pulmonary edema (70%) and diffuse alveolar damage at different stages. The immunohistochemical examination was positive for proteins of SARS-CoV-2 in 60% of cases on alveolocytes and in endothelial cells. The histopathological lung findings in the B.1.617.2 Delta variant are similar to those previously described in COVID-19. Spike protein-binding antibodies were identified immunohistochemically both on alveolocytes and in the endothelial cells, showing the potential of indirect damage from thrombosis. BACKGROUNDThe Delta variant (Pango lineage B.1.617.2) is one of the most significant and aggressive variants of SARS-CoV-2. To the best of our knowledge, this is the first paper specifically studying pulmonary morphopathology in COVID-19 caused by the B.1.617.2 Delta variant. METHODSThe study included 10 deceased patients (40-83 years) with the COVID-19 Delta variant. The necrotic lung fragments were obtained either by biopsy (six cases) or autopsy (four cases). Tissue samples were subjected to virology analysis for identification of the SARS-CoV-2 variant, histopathology, and immunohistochemistry (anti-SARS coronavirus mouse anti-virus antibody). RESULTSVirology analysis identified B.1.617.2 through genetic sequencing in eight cases, and in two cases, specific mutations of B.1.617.2 were identified. Macroscopically, in all autopsied cases, the lung had a particular appearance, purple in color, with increased consistency on palpation and abolished crepitations. Histopathologically, the most frequently observed lesions were acute pulmonary edema (70%) and diffuse alveolar damage at different stages. The immunohistochemical examination was positive for proteins of SARS-CoV-2 in 60% of cases on alveolocytes and in endothelial cells. CONCLUSIONSThe histopathological lung findings in the B.1.617.2 Delta variant are similar to those previously described in COVID-19. Spike protein-binding antibodies were identified immunohistochemically both on alveolocytes and in the endothelial cells, showing the potential of indirect damage from thrombosis. |
Audience | Academic |
Author | Anton, Vlad Gheban, Dan Mironescu, Daniela Inișca, Patricia Aluaș, Maria Jeican, Ionuț Isaia Vică, Mihaela Laura Rebeleanu, Codrin Lazăr, Mihaela Albu, Silviu Crivii, Carmen Bianca Siserman, Costel Vasile |
AuthorAffiliation | 7 Institute of Legal Medicine, 400006 Cluj-Napoca, Romania 10 Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babeș Str., No. 15, 400012 Cluj-Napoca, Romania 3 Department of Pathology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania 8 Department of Cell and Molecular Biology, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania 1 Department of Anatomy and Embryology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania 5 Department of Medical Biochemistry, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania 9 Department of Legal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania 4 Department of Pathology, Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania 6 Viral Respiratory Infections Laboratory, Cantacuzino National Military-Medical Institute for Research and Development, 050096 |
AuthorAffiliation_xml | – name: 9 Department of Legal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania – name: 4 Department of Pathology, Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania – name: 5 Department of Medical Biochemistry, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania – name: 6 Viral Respiratory Infections Laboratory, Cantacuzino National Military-Medical Institute for Research and Development, 050096 Bucharest, Romania – name: 8 Department of Cell and Molecular Biology, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania – name: 3 Department of Pathology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania – name: 11 Department of Head and Neck Surgery and Otorhinolaryngology, University Clinical Hospital of Railway Company, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania – name: 1 Department of Anatomy and Embryology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania – name: 7 Institute of Legal Medicine, 400006 Cluj-Napoca, Romania – name: 10 Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babeș Str., No. 15, 400012 Cluj-Napoca, Romania – name: 2 Department of Pathology, County Emergency Hospital Deva, 330084 Deva, Romania |
Author_xml | – sequence: 1 givenname: Ionuț Isaia orcidid: 0000-0002-3465-9474 surname: Jeican fullname: Jeican, Ionuț Isaia organization: Department of Anatomy and Embryology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania – sequence: 2 givenname: Patricia orcidid: 0000-0002-7502-7668 surname: Inișca fullname: Inișca, Patricia organization: Department of Pathology, County Emergency Hospital Deva, 330084 Deva, Romania – sequence: 3 givenname: Dan surname: Gheban fullname: Gheban, Dan organization: Department of Pathology, Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania – sequence: 4 givenname: Vlad surname: Anton fullname: Anton, Vlad organization: Department of Medical Biochemistry, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania – sequence: 5 givenname: Mihaela surname: Lazăr fullname: Lazăr, Mihaela organization: Viral Respiratory Infections Laboratory, Cantacuzino National Military-Medical Institute for Research and Development, 050096 Bucharest, Romania – sequence: 6 givenname: Mihaela Laura orcidid: 0000-0003-0811-0821 surname: Vică fullname: Vică, Mihaela Laura organization: Department of Cell and Molecular Biology, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania – sequence: 7 givenname: Daniela surname: Mironescu fullname: Mironescu, Daniela organization: Institute of Legal Medicine, 400006 Cluj-Napoca, Romania – sequence: 8 givenname: Codrin surname: Rebeleanu fullname: Rebeleanu, Codrin organization: Department of Legal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania – sequence: 9 givenname: Carmen Bianca orcidid: 0000-0001-5275-5753 surname: Crivii fullname: Crivii, Carmen Bianca organization: Department of Anatomy and Embryology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania – sequence: 10 givenname: Maria orcidid: 0000-0001-7051-3758 surname: Aluaș fullname: Aluaș, Maria organization: Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babeș Str., No. 15, 400012 Cluj-Napoca, Romania – sequence: 11 givenname: Silviu orcidid: 0000-0002-2858-8470 surname: Albu fullname: Albu, Silviu organization: Department of Head and Neck Surgery and Otorhinolaryngology, University Clinical Hospital of Railway Company, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania – sequence: 12 givenname: Costel Vasile orcidid: 0000-0002-6124-8582 surname: Siserman fullname: Siserman, Costel Vasile organization: Department of Legal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania |
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CitedBy_id | crossref_primary_10_3390_biomedicines11082113 crossref_primary_10_3390_medicina59091616 crossref_primary_10_3390_diagnostics14030294 |
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Snippet | The Delta variant (Pango lineage B.1.617.2) is one of the most significant and aggressive variants of SARS-CoV-2. To the best of our knowledge, this is the... Background: The Delta variant (Pango lineage B.1.617.2) is one of the most significant and aggressive variants of SARS-CoV-2. To the best of our knowledge,... BACKGROUNDThe Delta variant (Pango lineage B.1.617.2) is one of the most significant and aggressive variants of SARS-CoV-2. To the best of our knowledge, this... |
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SubjectTerms | Alveoli Analysis Autopsies Autopsy B.1.617.2 Biopsy Coronaviruses COVID-19 Delta variant Edema Endothelial cells Ethylenediaminetetraacetic acid Genomes Health aspects Histopathology Immunohistochemistry Infections Legal medicine lung Medical research Medicine, Experimental Mutation Precision medicine Protein binding Proteins Severe acute respiratory syndrome coronavirus 2 Spike protein Thrombosis Virology |
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Title | Histopathological Lung Findings in COVID-19 B.1.617.2 SARS-CoV-2 Delta Variant |
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