Coumarin Metabolism, Toxicity and Carcinogenicity: Relevance for Human Risk Assessment - Lake, B.G (Food and Chemical Toxicology, 1999)
Keywords: animal models; Animals; Biological and medical sciences; carcinogenesis; Carcinogens; Carcinogens - toxicity; Cosmetics; Cosmetics - standards; coumarin; Coumarins; Coumarins - metabolism; Coumarins - toxicity; Cricetinae; Food Contamination; Food toxicology; fragrances; Humans; interspecific variation; Intestinal Absorption; laboratory animals; literature reviews; liver tumours; lung tumours; Medical sciences; metabolism; Mice; Mutagenicity Tests; Rats; Risk Assessment; species differences; toxicity; Toxicity Tests; Toxicology; tumorigenesis; GSH=reduced glutathione; risk assessment; o-HPLA= o-hydroxyphenyllactic acid; 5-HC=5-hydroxycoumarin; liver tumours; o-CA= o-coumaric acid; o-HPA= o-hydroxyphenylacetaldehyde; 4-HDHC–GSH conjugate=4-hydroxydihydrocoumarin–glutathione conjugate; 6-HC=6-hydroxycoumarin; DHC=dihydrocoumarin; species differences; CHO=Chinese hamster ovary; o-HPAA= o-hydroxyphenylacetic acid; NOEL=no-observed-effect level; UDS=unscheduled DNA synthesis; CYP=cytochrome P-450; 7-HC=7-hydroxycoumarin; coumarin; 3-HC=3-hydroxycoumarin; o-HPE= o-hydroxyphenylethanol; GSSG=oxidized glutathione; o-HPPA= o-hydroxyphenylpropionic acid; 6,7-diHC=6,7-dihydroxycoumarin; 8-HC=8-hydroxycoumarin; lung tumours; 4-HC=4-hydroxycoumarin; metabolism; NTP=National Toxicology Program; Cosmetic; Human; Evaluation; Toxicity; Interspecific comparison; Liver; Lung; Review; Harmlessness; Malignant tumor; No observed effect level; Metabolism; Coumarin; Carcinogen; Animal; Food